D
David E. Newby
Researcher at University of Edinburgh
Publications - 902
Citations - 45577
David E. Newby is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Myocardial infarction & Coronary artery disease. The author has an hindex of 98, co-authored 805 publications receiving 35865 citations. Previous affiliations of David E. Newby include NHS Lothian & Queen's University.
Papers
More filters
Journal ArticleDOI
Rationale and design of the randomized, controlled Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis (EVOLVED) trial.
Rong Bing,Russell J. Everett,Chris Tuck,Scott Ian Kay Semple,Steff Lewis,Ronnie Harkess,Nicholas L. Mills,Thomas A. Treibel,Sanjay K Prasad,John P Greenwood,Gerry P McCann,David E. Newby,Marc R. Dweck +12 more
TL;DR: The EVOLVED trial is the first multicenter randomized controlled trial to compare early aortic valve replacement to routine care in asymptomatic patients with severe aorti stenosis and midwall LGE.
Posted Content
A two-stage 3D Unet framework for multi-class segmentation on full resolution image
TL;DR: A two-stage modified Unet framework that simultaneously learns to detect a ROI within the full volume and to classify voxels without losing the original resolution is developed.
Journal ArticleDOI
Pulmonary diesel particulate increases susceptibility to myocardial ischemia/reperfusion injury via activation of sensory TRPV1 and β1 adrenoreceptors
Sarah Robertson,Sarah Robertson,Ashleigh L Thomson,Rod Carter,Holly R Stott,Catherine A Shaw,Patrick W. F. Hadoke,David E. Newby,Mark R. Miller,Gillian A. Gray +9 more
TL;DR: Pulmonary diesel exhaust particulate increases blood pressure and has a profound adverse effect on the myocardium, resulting in tissue damage, but also increases vulnerability to ischemia-associated arrhythmia and reperfusion injury.
Journal ArticleDOI
Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury: from epithelium to endothelium.
TL;DR: The beneficial effects of elafin inhibition of neutrophil elastase and its extended anti-inflammatory activity in pre-clinical models of inflammatory vascular injury are discussed.
Journal ArticleDOI
Exposure to nitrogen dioxide is not associated with vascular dysfunction in man
Jeremy P. Langrish,Magnus Lundbäck,Stefan Barath,Stefan Söderberg,Nicholas L. Mills,David E. Newby,Thomas Sandström,Anders Blomberg +7 more
TL;DR: Inhalation of nitrogen dioxide does not appear to be a major arbiter of the adverse cardiovascular effects of air pollution, and vascular vasomotor and six fibrinolytic functions are unaffected.