D
David E. Newby
Researcher at University of Edinburgh
Publications - 902
Citations - 45577
David E. Newby is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Myocardial infarction & Coronary artery disease. The author has an hindex of 98, co-authored 805 publications receiving 35865 citations. Previous affiliations of David E. Newby include NHS Lothian & Queen's University.
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Journal ArticleDOI
In Vivo Alpha-V Beta-3 Integrin Expression in Human Aortic Atherosclerosis
William Jenkins,William Jenkins,Alex T. Vesey,Anna Vickers,Anoushka Neale,Catriona Moles,Martin Connell,Nikhil Joshi,Christophe Lucatelli,Alison Fletcher,James C Spratt,Saeed Mirsadraee,Edwin J.R. van Beek,James H.F. Rudd,David E. Newby,Marc R. Dweck +15 more
TL;DR: In vivo expression of αvβ3 integrin in human aortic atheroma is associated with plaque burden and is increased in patients with recent myocardial infarction, and Quantification of α vβ3integrin expression with 18F-fluciclatide PET has potential to assess plaque vulnerability and disease activity in atherosclerosis.
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Salt in the wound: (18)F-fluoride positron emission tomography for identification of vulnerable coronary plaques.
TL;DR: The utility of PET-CT using (18)F-fluoride and (18).F-FDG to detect high-risk or ruptured atherosclerotic plaques in vivo and the limitations of the current approach of vulnerable plaque assessment are compared.
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Randomized Controlled Trial of Dual Antiplatelet Therapy in Patients Undergoing Surgery for Critical Limb Ischemia
Anne Burdess,Alastair F. Nimmo,O. James Garden,J. A. Murie,A. Raymond W. Dawson,Keith A.A. Fox,David E. Newby +6 more
TL;DR: In patients with critical limb ischemia, perioperative dual antiplatelet therapy reduces biomarkers of atherothrombosis without causing unacceptable bleeding.
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P-selectin antagonism reduces thrombus formation in humans.
R Chelliah,Andrew J. Lucking,Laura C Tattersall,Shruti Daga,N. J. Beresford-Cleary,K. Cortas,Keith A.A. Fox,Giora Z. Feuerstein,T M Connolly,David E. Newby +9 more
TL;DR: P‐selectin antagonism with PSI‐697 reduces ex vivo thrombus formation in humans, providing further evidence that P‐select in antagonism may be a potential target for the prevention and treatment of cardiovascular disease.
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Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans
Ingibjörg J. Guðmundsdóttir,Ninian N. Lang,Nicholas A. Boon,Christopher A. Ludlam,David J. Webb,Keith A.A. Fox,David E. Newby +6 more
TL;DR: Acting via PAR-1, thrombin causes contrasting effects in the human vasculature and has a major interaction with the endothelium, highlighting the critical importance of endothelial function during acute arterial injury and intravascular thrombosis, as occurs in cardiovascular events including myocardial infarction and stroke.