L
Lukasz Goldschmidt
Researcher at University of California, Los Angeles
Publications - 17
Citations - 3137
Lukasz Goldschmidt is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Protein structure & Protein folding. The author has an hindex of 13, co-authored 17 publications receiving 2466 citations. Previous affiliations of Lukasz Goldschmidt include University of Washington & Howard Hughes Medical Institute.
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Journal ArticleDOI
Identifying the amylome, proteins capable of forming amyloid-like fibrils
TL;DR: The amylome is the universe of proteins that are capable of forming amyloid-like fibrils and the presence in the protein of a segment that can form a tightly complementary interface with an identical segment permits the formation of a steric zipper.
Journal ArticleDOI
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Julia Koehler Leman,Brian D. Weitzner,Brian D. Weitzner,Steven M. Lewis,Steven M. Lewis,Jared Adolf-Bryfogle,Nawsad Alam,Rebecca F. Alford,Melanie L. Aprahamian,David Baker,Kyle A. Barlow,Patrick Barth,Patrick Barth,Benjamin Basanta,Brian J. Bender,Kristin Blacklock,Jaume Bonet,Jaume Bonet,Scott E. Boyken,Phil Bradley,Christopher Bystroff,Patrick Conway,Seth Cooper,Bruno E. Correia,Bruno E. Correia,Brian Coventry,Rhiju Das,René M. de Jong,Frank DiMaio,Lorna Dsilva,Roland L. Dunbrack,Alex Ford,Brandon Frenz,Darwin Y. Fu,Caleb Geniesse,Lukasz Goldschmidt,Ragul Gowthaman,Jeffrey J. Gray,Dominik Gront,Sharon L. Guffy,Scott Horowitz,Po-Ssu Huang,Thomas Huber,Timothy M. Jacobs,Jeliazko R. Jeliazkov,David K. Johnson,Kalli Kappel,John Karanicolas,Hamed Khakzad,Hamed Khakzad,Karen R. Khar,Sagar D. Khare,Firas Khatib,Alisa Khramushin,Indigo Chris King,Robert Kleffner,Brian Koepnick,Tanja Kortemme,Georg Kuenze,Brian Kuhlman,Daisuke Kuroda,Jason W. Labonte,Jason W. Labonte,Jason K. Lai,Gideon Lapidoth,Andrew Leaver-Fay,Steffen Lindert,Thomas W. Linsky,Nir London,Joseph H. Lubin,Sergey Lyskov,Jack Maguire,Lars Malmström,Lars Malmström,Lars Malmström,Enrique Marcos,Orly Marcu,Nicholas A. Marze,Jens Meiler,Rocco Moretti,Vikram Khipple Mulligan,Santrupti Nerli,Christoffer Norn,Shane O’Conchúir,Noah Ollikainen,Sergey Ovchinnikov,Michael S. Pacella,Xingjie Pan,Hahnbeom Park,Ryan E. Pavlovicz,Manasi A. Pethe,Brian G. Pierce,Kala Bharath Pilla,Barak Raveh,P. Douglas Renfrew,Shourya S. Roy Burman,Aliza B. Rubenstein,Marion F. Sauer,Andreas Scheck,Andreas Scheck,William R. Schief,Ora Schueler-Furman,Yuval Sedan,Alexander M. Sevy,Nikolaos G. Sgourakis,Lei Shi,Justin B. Siegel,Daniel-Adriano Silva,Shannon Smith,Yifan Song,Amelie Stein,Maria Szegedy,Frank D. Teets,Summer B. Thyme,Ray Yu-Ruei Wang,Andrew M. Watkins,Lior Zimmerman,Richard Bonneau +117 more
TL;DR: This Perspective reviews tools developed over the past five years in the Rosetta software, including over 80 methods, and discusses improvements to the score function, user interfaces and usability.
Journal ArticleDOI
Molecular basis for amyloid-beta polymorphism.
Jacques-Philippe Colletier,Arthur Laganowsky,Meytal Landau,Minglei Zhao,A.B. Soriaga,Lukasz Goldschmidt,David Flot,Duilio Cascio,Michael R. Sawaya,David Eisenberg +9 more
TL;DR: To elucidate Aβ polymorphism in atomic detail, eight new microcrystal structures of fiber-forming segments of A β are determined, all of short, self-complementing pairs of β-sheets termed steric zippers, revealing a variety of modes of self-association of Aβ.
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Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
Michael P. Hughes,Michael R. Sawaya,David R. Boyer,Lukasz Goldschmidt,Jose A. Rodriguez,Duilio Cascio,Lisa Chong,Tamir Gonen,David Eisenberg +8 more
TL;DR: The atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies, found in proteins as diverse as RNA binders, nuclear pore proteins, and keratins, are determined, which suggest that short segments of two such domains can bind weakly to each other by forming a pair of kinked β-sheets.
Journal ArticleDOI
Toward rational protein crystallization: A Web server for the design of crystallizable protein variants
TL;DR: A Web server, the surface entropy reduction prediction server (SERp server), designed to identify mutations that may facilitate crystallization and an attempt to benchmark the server by comparing the server's predictions with successful SER structures.