D
David Freestone
Researcher at University of Melbourne
Publications - 9
Citations - 1599
David Freestone is an academic researcher from University of Melbourne. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 5, co-authored 6 publications receiving 1284 citations.
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Journal ArticleDOI
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.
Laura K. Mackay,Laura K. Mackay,Martina Minnich,Natasja A. M. Kragten,Yang Liao,Yang Liao,Benjamin Nota,Cyril Seillet,Cyril Seillet,Ali Zaid,Kevin Man,Kevin Man,Simon Preston,Simon Preston,David Freestone,Asolina Braun,Erica Wynne-Jones,Felix M. Behr,Regina Stark,Daniel G. Pellicci,Daniel G. Pellicci,Dale I. Godfrey,Dale I. Godfrey,Gabrielle T. Belz,Gabrielle T. Belz,Marc Pellegrini,Marc Pellegrini,Thomas Gebhardt,Meinrad Busslinger,Wei Shi,Wei Shi,Francis R. Carbone,René A. W. van Lier,Axel Kallies,Axel Kallies,Klaas P. J. M. van Gisbergen +35 more
TL;DR: In this paper, the authors identify Hobit and Blimp1 as central regulators of a universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations, including NKT cells and liver-resident NK cells.
Journal ArticleDOI
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate
Laura K. Mackay,Erica Wynne-Jones,David Freestone,Daniel G. Pellicci,Daniel G. Pellicci,Lisa A. Mielke,Dane M. Newman,Asolina Braun,Frederick Masson,Frederick Masson,Axel Kallies,Gabrielle T. Belz,Francis R. Carbone +12 more
TL;DR: It is demonstrated that the T-box transcription factors Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-β cytokine signaling.
Journal Article
Hobit and Blimp1 instruct a universal transcriptional program of tissue-residency in lymphocytes
Laura K. Mackay,Martina Minnich,Natasja A. M. Kragten,Cyril Seillet,David Freestone,Gabrielle T. Belz,Meinrad Busslinger,Wei Shi,Francis R. Carbone,R. A. W. Van Lier,Axel Kallies,K van Gisbergen +11 more
TL;DR: It is shown that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trms cells in skin, gut, liver, and kidney in mice.
Journal ArticleDOI
Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes
Hannah Frizzell,Raissa Fonseca,Susan N Christo,Maximilien Evrard,S. Cruz-Gomez,N. G. Zanluqui,N. G. Zanluqui,B. von Scheidt,David Freestone,Simone L Park,Hamish E G McWilliam,Jose A Villadangos,Francis R. Carbone,Laura K. Mackay +13 more
TL;DR: It is shown that although TRM cells in a range of tissue widely express FABPs, they are not restricted to FABP4 and FABp5, and show varying patterns of isoform usage that are determined by tissue-derived factors.
Journal ArticleDOI
CD8 + T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver
Lauren E. Holz,Julia E. Prier,David Freestone,Thiago M. Steiner,Kieran English,Darryl N. Johnson,Vanessa Mollard,Anton Cozijnsen,Gayle M. Davey,Dale I. Godfrey,Katsuyuki Yui,Laura K. Mackay,Mireille H. Lahoud,Irina Caminschi,Geoffrey I. McFadden,Patrick Bertolino,Daniel Fernandez-Ruiz,William R. Heath +17 more
TL;DR: The findings indicate that liver Trm cells form as a normal consequence of CD8+ T cell activation during essentially any infection but that inflammatory and antigenic signals preferentially tailor their development.