D
Derek Drake
Researcher at Harvard University
Publications - 6
Citations - 1160
Derek Drake is an academic researcher from Harvard University. The author has contributed to research in topics: Longevity & Gene. The author has an hindex of 5, co-authored 5 publications receiving 905 citations.
Papers
More filters
Journal ArticleDOI
REST and stress resistance in ageing and Alzheimer’s disease
Tao Lu,Liviu Aron,Joseph M. Zullo,Ying Pan,Haeyoung Kim,Yiwen Chen,Tun Hsiang Yang,Hyun-Min Kim,Derek Drake,X. Shirley Liu,David A. Bennett,Monica P. Colaiácovo,Bruce A. Yankner +12 more
TL;DR: It is shown that induction of the repressor element 1-silencing transcription factor (REST) is a universal feature of normal ageing in human cortical and hippocampal neurons, and levels during ageing are closely correlated with cognitive preservation and longevity.
Journal ArticleDOI
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Solveig K. Sieberts,Thanneer M. Perumal,Minerva M. Carrasquillo,Mariet Allen,Joseph S. Reddy,Gabriel E. Hoffman,Kristen K. Dang,John N. Calley,Phillip J. Ebert,James A. Eddy,Xue Wang,Anna K. Greenwood,Sara Mostafavi,Sara Mostafavi,S Akbarian,J Bendl,M S Breen,K Brennand,L Brown,A Browne,J D Buxbaum,A Charney,Andrew Chess,Couto L,Gregory E. Crawford,Devillers O,Bernie Devlin,Amanda Dobbyn,E Domenici,M Filosi,E Flatow,Nancy Francoeur,John F. Fullard,S E Gil,Kiran Girdhar,A Gulyás-Kovács,R.E. Gur,C G Hahn,Vahram Haroutunian,Mads E. Hauberg,Laura M. Huckins,Rivka Jacobov,Y Jiang,Jessica S. Johnson,Bibi Kassim,Y Kim,Lambertus Klei,Robin Kramer,Mario Lauria,Thomas Lehner,David A. Lewis,Barbara K. Lipska,Kelsey S. Montgomery,R Park,C Rosenbluh,Panagiotis Roussos,Douglas M. Ruderfer,G Senthil,Hardik Shah,Laura G. Sloofman,L Song,E Stahl,P.F. Sullivan,R Visintainer,J Wang,Y C Wang,Jennifer Wiseman,E Xia,W Zhang,Elizabeth Zharovsky,L Addis,S N Addo,David C. Airey,Matthias Arnold,David A. Bennett,Y Bi,K Biber,Colette Blach,E Bradhsaw,Paul Brennan,R Canet-Aviles,S Cao,A Cavalla,Yooree Chae,W W Chen,J Cheng,David A. Collier,J L Dage,Eric B. Dammer,J W Davis,John B. Davis,Derek Drake,D Duong,Brian J. Eastwood,Michelle E. Ehrlich,B Ellingson,B W Engelmann,S Esmaeelinieh,Daniel Felsky,Cory C. Funk,Chris Gaiteri +100 more
TL;DR: A colocalization analysis is applied to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalized with lncRNA RP11-677M14.
Journal ArticleDOI
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Katharina Meyer,Heather M. Feldman,Tao Lu,Derek Drake,Elaine T. Lim,King Hwa Ling,Nicholas A. Bishop,Ying Pan,Jinsoo Seo,Yuan Ta Lin,Susan C. Su,George M. Church,George M. Church,Li-Huei Tsai,Bruce A. Yankner +14 more
TL;DR: The iPSC-derived neural cells from SAD patients exhibit accelerated neural differentiation and reduced progenitor cell renewal, and a similar phenotype appears in NP cells and cerebral organoids derived from APOE4 iPSCs.
Journal ArticleDOI
Regulation of lifespan by neural excitation and REST
Joseph M. Zullo,Derek Drake,Liviu Aron,Patrick O’Hern,Sameer C. Dhamne,Noah Davidsohn,Chai An Mao,William H. Klein,Alexander Rotenberg,David A. Bennett,George M. Church,Monica P. Colaiácovo,Bruce A. Yankner +12 more
TL;DR: It is shown that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function, which reveals a conserved mechanism of ageing that is mediated by neural circuit activity and regulated by REST.
Journal ArticleDOI
Addendum: REST and stress resistance in ageing and Alzheimer’s disease
Tao Lu,Liviu Aron,Joseph M. Zullo,Ying Pan,Haeyoung Kim,Yiwen Chen,Tun-Hsiang Yang,Hyun-Min Kim,Derek Drake,X. Shirley Liu,David A. Bennett,Monica P. Colaiácovo,Bruce A. Yankner +12 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, called a “shots fired” process.