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Bibi Kassim
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 21
Citations - 977
Bibi Kassim is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 10, co-authored 17 publications receiving 685 citations. Previous affiliations of Bibi Kassim include University of York.
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Journal ArticleDOI
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Solveig K. Sieberts,Thanneer M. Perumal,Minerva M. Carrasquillo,Mariet Allen,Joseph S. Reddy,Gabriel E. Hoffman,Kristen K. Dang,John N. Calley,Phillip J. Ebert,James A. Eddy,Xue Wang,Anna K. Greenwood,Sara Mostafavi,Sara Mostafavi,S Akbarian,J Bendl,M S Breen,K Brennand,L Brown,A Browne,J D Buxbaum,A Charney,Andrew Chess,Couto L,Gregory E. Crawford,Devillers O,Bernie Devlin,Amanda Dobbyn,E Domenici,M Filosi,E Flatow,Nancy Francoeur,John F. Fullard,S E Gil,Kiran Girdhar,A Gulyás-Kovács,R.E. Gur,C G Hahn,Vahram Haroutunian,Mads E. Hauberg,Laura M. Huckins,Rivka Jacobov,Y Jiang,Jessica S. Johnson,Bibi Kassim,Y Kim,Lambertus Klei,Robin Kramer,Mario Lauria,Thomas Lehner,David A. Lewis,Barbara K. Lipska,Kelsey S. Montgomery,R Park,C Rosenbluh,Panagiotis Roussos,Douglas M. Ruderfer,G Senthil,Hardik Shah,Laura G. Sloofman,L Song,E Stahl,P.F. Sullivan,R Visintainer,J Wang,Y C Wang,Jennifer Wiseman,E Xia,W Zhang,Elizabeth Zharovsky,L Addis,S N Addo,David C. Airey,Matthias Arnold,David A. Bennett,Y Bi,K Biber,Colette Blach,E Bradhsaw,Paul Brennan,R Canet-Aviles,S Cao,A Cavalla,Yooree Chae,W W Chen,J Cheng,David A. Collier,J L Dage,Eric B. Dammer,J W Davis,John B. Davis,Derek Drake,D Duong,Brian J. Eastwood,Michelle E. Ehrlich,B Ellingson,B W Engelmann,S Esmaeelinieh,Daniel Felsky,Cory C. Funk,Chris Gaiteri +100 more
TL;DR: A colocalization analysis is applied to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalized with lncRNA RP11-677M14.
Journal ArticleDOI
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.
Prashanth Rajarajan,Tyler M. Borrman,Will Liao,Nadine Schrode,Erin Flaherty,Charlize Casiño,Samuel K. Powell,Chittampalli Yashaswini,Elizabeth A. LaMarca,Bibi Kassim,Behnam Javidfar,Sergio Espeso-Gil,Aiqun Li,Hyejung Won,Daniel H. Geschwind,Seok-Man Ho,Matthew L. MacDonald,Gabriel E. Hoffman,Panos Roussos,Bin Zhang,Chang-Gyu Hahn,Zhiping Weng,Kristen J. Brennand,Schahram Akbarian +23 more
TL;DR: This study shows that neural differentiation is associated with highly cell type–specific 3DG remodeling, which is paralleled by an expansion of3DG space associated with SZ risk, and tests whether the neural cell–specific SZ-related “chromosomal connectome” showed evidence of coordinated transcriptional regulation and proteomic interaction of the participating genes.
Journal ArticleDOI
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Yan Jiang,Yong-Hwee E. Loh,Prashanth Rajarajan,Teruyoshi Hirayama,Will Liao,Bibi Kassim,Behnam Javidfar,Brigham J. Hartley,Lisa Kleofas,Royce Park,Benoit Labonté,Seok-Man Ho,Sandhya Chandrasekaran,Catherine Do,Brianna R. Ramirez,Cyril J. Peter,Julia T.C.W.,Brian M. Safaie,Hirofumi Morishita,Panos Roussos,Eric J. Nestler,Anne Schaefer,Benjamin Tycko,Kristen J. Brennand,Takeshi Yagi,Li Shen,Schahram Akbarian +26 more
TL;DR: It is shown that the SETDB1 repressor complex, which involves multiple KRAB zinc finger proteins, shields neuronal genomes from excess CTCF binding and is critically required for structural maintenance of TADcPcdh.
Journal ArticleDOI
Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.
Kiran Girdhar,Gabriel E. Hoffman,Yan Jiang,Leanne Brown,Marija Kundakovic,Marija Kundakovic,Mads E. Hauberg,Mads E. Hauberg,Nancy Francoeur,Ying-Chih Wang,Hardik Shah,David H. Kavanagh,Elizabeth Zharovsky,Rivka Jacobov,Jennifer Wiseman,Royce Park,Jessica S. Johnson,Bibi Kassim,Laura G. Sloofman,Eugenio Mattei,Zhiping Weng,Solveig K. Sieberts,Mette A. Peters,Brent T. Harris,Brent T. Harris,Barbara K. Lipska,Pamela Sklar,Panos Roussos,Panos Roussos,Schahram Akbarian +29 more
TL;DR: This PsychENCODE resource presents 157 reference maps for open-chromatin-associated histone methylation and acetylation in prefrontal and anterior cingulate cortex, linking the neuronal epigenome to the genetic risk architecture of schizophrenia.
Journal ArticleDOI
Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue
Marija Kundakovic,Yan Jiang,David H. Kavanagh,Aslihan Dincer,Leanne Brown,Venu Pothula,Elizabeth Zharovsky,Royce Park,Rivka Jacobov,Isabelle Magro,Bibi Kassim,Jennifer Wiseman,Kristen K. Dang,Solveig K. Sieberts,Panos Roussos,Menachem Fromer,Brent T. Harris,Brent T. Harris,Barbara K. Lipska,Mette A. Peters,Pamela Sklar,Schahram Akbarian +21 more
TL;DR: A ChIP-seq pipeline for epigenome mapping in the neuronal and nonneuronal nuclei from the postmortem brain is presented, including a stepwise system of quality controls and user-friendly data presentation platforms.