D
Derrick W. Crook
Researcher at University of Oxford
Publications - 510
Citations - 38699
Derrick W. Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 92, co-authored 474 publications receiving 29885 citations. Previous affiliations of Derrick W. Crook include Oxford Brookes University & The Chinese University of Hong Kong.
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Journal ArticleDOI
Accuracy of different bioinformatics methods in detecting antibiotic resistance and virulence factors from Staphylococcus aureus whole genome sequences.
Amy M. Mason,Dona Foster,Phelim Bradley,Tanya Golubchik,Michel Doumith,N. Claire Gordon,Bruno Pichon,Zamin Iqbal,Peter Staves,Derrick W. Crook,A. Sarah Walker,A. Sarah Walker,Angela Kearns,Angela Kearns,Tim E. A. Peto,Tim E. A. Peto +15 more
TL;DR: This study compared three WGS-based bioinformatics methods for predicting the presence/absence of 83 different resistance determinants and virulence genes and overall antimicrobial susceptibility in 1,379 Staphylococcus aureus isolates previously characterized by standard laboratory methods.
Journal ArticleDOI
Whole-Genome Sequencing Demonstrates That Fidaxomicin Is Superior to Vancomycin for Preventing Reinfection and Relapse of Infection With Clostridium difficile
David W Eyre,Farah Babakhani,David Griffiths,Jaime Seddon,Carlos del Ojo Elias,Sherwood L. Gorbach,Tim E. A. Peto,Derrick W. Crook,A. Sarah Walker +8 more
TL;DR: Whole-genome sequencing was used to determine whether the reductions in recurrence of Clostridium difficile infection observed with fidaxomicin in pivotal phase 3 trials occurred by preventing relapse of the same infection, by preventing reinfection with a new strain, or by preventing both outcomes.
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A Quantitative Evaluation of MIRU-VNTR Typing Against Whole-Genome Sequencing for Identifying Mycobacterium tuberculosis Transmission: A Prospective Observational Cohort Study.
David H. Wyllie,David H. Wyllie,Jennifer Davidson,Grace Smith,Priti Rathod,Derrick W. Crook,Derrick W. Crook,Tim E. A. Peto,Tim E. A. Peto,Esther Robinson,Timothy M Walker,Colin Campbell +11 more
TL;DR: This molecular epidemiological study shows MIRU-VNTR typing and epidemiological risk factors are poorly predictive of close genomic relatedness, assessed by SNV.
Journal ArticleDOI
Molecular typing of bacteria directly from cerebrospinal fluid
TL;DR: The ability of multilocus sequence typing (MLST) to characterise isolates directly from cerebrospinal fluid (CSF) was investigated and it was found that MLST could predict the penicillin susceptibility and serotype of the CSF isolates.
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Stable and Noncompetitive RNA Internal Control for Routine Clinical Diagnostic Reverse Transcription-PCR
TL;DR: A reaction-specific RNA internal control for diagnostic reverse transcription (RT)-PCR which allows extraction, RT, amplification, and detection to be monitored, and ensures that genuine and false-negative results were distinguishable, thus increasing the diagnostic confidence in the assay.