D
Derrick W. Crook
Researcher at University of Oxford
Publications - 510
Citations - 38699
Derrick W. Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 92, co-authored 474 publications receiving 29885 citations. Previous affiliations of Derrick W. Crook include Oxford Brookes University & The Chinese University of Hong Kong.
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SARS-CoV-2 infectivity by viral load, S gene variants and demographic factors and the utility of lateral flow devices to prevent transmission
Lennard Y. W. Lee,Stefan Rozmanowski,Matthew Pang,Andre Charlett,Charlotte Anderson,Gareth Hughes,Matthew Barnard,Leon Peto,Richard Vipond,Alex Sienkiewicz,Susan R. Hopkins,John Bell,Derrick W. Crook,Nick Gent,A. Sarah Walker,Tim E. A. Peto,David W Eyre +16 more
TL;DR: In this article, the authors used multivariable logistic regression to investigate relationships between PCR-confirmed infection in contacts of community-diagnosed cases and index case viral load, S gene target failure (proxy for B.1.7 infection), demographics, SARS-CoV-2 incidence, social deprivation, and contact event type.
Posted ContentDOI
Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches
Joshua Carter,Timothy M Walker,A. Sarah Walker,Michael G. Whitfield,Glenn P. Morlock,Tim E. A. Peto,James E. Posey,Derrick W. Crook,Derrick W. Crook,Philip W. Fowler +9 more
TL;DR: An approach to improve the sensitivity/specificity of pyrazinamide resistance prediction in genetics-based clinical microbiology workflows, highlights novel mutations for future biochemical investigation, and is a proof of concept for using this approach in other drugs such as bedaquiline.
Journal ArticleDOI
Multi-Label Random Forest Model for Tuberculosis Drug Resistance Classification and Mutation Ranking.
Samaneh Kouchaki,Yang Yang,Alexander Lachapelle,Timothy M Walker,Timothy M Walker,A. Sarah Walker,A. Sarah Walker,Tim E. A. Peto,Tim E. A. Peto,Derrick W. Crook,Derrick W. Crook,David A. Clifton +11 more
TL;DR: Multi-label random forest models are compared with single-label Random Forest models for both predicting phenotypic resistance from whole genome sequences and identifying important mutations for better prediction of four first-line drugs in a dataset of Mycobacterium tuberculosis isolates.
Journal ArticleDOI
Clinical Metagenomic Sequencing for Species Identification and Antimicrobial Resistance Prediction in Orthopedic Device Infection
Teresa L Street,Nicholas D Sanderson,Camille Kolenda,James Kavanagh,H Pickford,Sarah Hoosdally,Jan Cregan,Carol Taunt,Emma Jones,Sarah Oakley,Bridget L. Atkins,Maria Dudareva,Martin A. McNally,Justin O'Grady,Derrick W. Crook,David W Eyre +15 more
TL;DR: Metagenomic nanopore sequencing coupled with human DNA depletion has the potential to detect AMR in addition to species detection in orthopedic device-related infection.
Journal ArticleDOI
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Sheila F Lumley,David W Eyre,Anna L McNaughton,A Howarth,Sarah Hoosdally,Stephanie B Hatch,James Kavanagh,Kevin K Chau,Louise O Downs,S Cox,Laura Dunn,Anita Justice,Susan Wareing,Kate E. Dingle,Justine K. Rudkin,Kathryn Auckland,Alex Fyfe,Jai S Bolton,Robert S. Paton,Alexander J. Mentzer,Katie Jeffery,Monique Andersson,Tim James,Peto Tea.,Brian D. Marsden,Gavin R. Screaton,Richard J. Cornall,Paul Klenerman,Paul Klenerman,Daniel Ebner,David I. Stuart,David I. Stuart,Derrick W. Crook,Nicole Stoesser,Stephen Kennedy,Craig Thompson,Sunetra Gupta,Philippa C Matthews +37 more
TL;DR: SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area between 14 April and 15 June 2020 yielded a 5.3% seroprevalence, mirroring contemporaneous regional data.