D
Derrick W. Crook
Researcher at University of Oxford
Publications - 510
Citations - 38699
Derrick W. Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 92, co-authored 474 publications receiving 29885 citations. Previous affiliations of Derrick W. Crook include Oxford Brookes University & The Chinese University of Hong Kong.
Papers
More filters
Journal ArticleDOI
Whole genome sequencing for M/XDR tuberculosis surveillance and for resistance testing.
Timothy M Walker,Matthias Merker,Thomas Kohl,Derrick W. Crook,Derrick W. Crook,Stefan Niemann,T Peto,T Peto +7 more
TL;DR: Some of the challenges to characterizing the Mycobacterium tuberculosis 'resistome'-the optimal knowledge-base required for WGS-based assays to successfully direct individualized treatment regimens through the prediction of drug resistance and susceptibility in the future are discussed.
Journal ArticleDOI
High rates of human fecal carriage of mcr-1-positive multidrug-resistant Enterobacteriaceae emerge in China in association with successful plasmid families.
Lan Lan Zhong,Hang T. T. Phan,Cong Shen,Karina Doris Vihta,Anna E. Sheppard,Xi Huang,Kun Jiao Zeng,Hongyu Li,Xue Fei Zhang,Sandip Patil,Derrick W. Crook,A. Sarah Walker,Yong Xing,Jia lin Lin,Lian Qiang Feng,Yohei Doi,Yong Xia,Nicole Stoesser,Guo-Bao Tian +18 more
TL;DR: The high prevalence of mcr-1 in multidrug-resistant E. coli colonizing humans is a clinical threat; diverse genetic mechanisms (strains/plasmids/insertion sequences) have contributed to the dissemination of mCr-1, and will facilitate its persistence.
Journal ArticleDOI
The evolution of genetic structure in the marine pathogen, Vibrio vulnificus.
Naiel Bisharat,Daniel Cohen,Martin C. J. Maiden,Derrick W. Crook,Tim E. A. Peto,Rosalind M. Harding +5 more
TL;DR: Multi-locus sequence types from a global collection of Vibrio vulnificus isolates were analysed for the contribution of recombination to the evolution of two divergent clusters of strains and a human-pathogenic hybrid genotype, which caused a disease outbreak in Israel.
Journal ArticleDOI
Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.
Rancoita Pmv,Federica Cugnata,Ana Luíza Gibertoni Cruz,Emanuele Borroni,Sarah Hoosdally,Timothy M Walker,Clara Grazian,Timothy J Davies,Peto Tea.,Derrick W. Crook,Philip W. Fowler,Daniela Maria Cirillo +11 more
TL;DR: Early evidence is provided that the UKMYC5 plate can quantitatively measure the magnitude of resistance to anti-TB compounds that is due to specific genetic variation.
Posted ContentDOI
Comparison of long-read sequencing technologies in the hybrid assembly of complex bacterial genomes
Nicola De Maio,Liam P. Shaw,Alasdair T. M. Hubbard,Sophie George,Sophie George,Nicholas D Sanderson,Jeremy Swann,Ryan R. Wick,Manal AbuOun,Emma Stubberfield,Sarah Hoosdally,Derrick W. Crook,Derrick W. Crook,Tim E. A. Peto,Tim E. A. Peto,Anna E. Sheppard,Anna E. Sheppard,Mark J. Bailey,Daniel S. Read,Muna F. Anjum,A. Sarah Walker,A. Sarah Walker,Nicole Stoesser +22 more
TL;DR: It is shown that automated hybrid assembly can automatically fully reconstruct complex bacterial genomes of Enterobacteriaceae isolates in the majority of cases and represents a low-cost, high-quality approach for reconstructing bacterial genomes using publicly available software.