D
Derrick W. Crook
Researcher at University of Oxford
Publications - 510
Citations - 38699
Derrick W. Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 92, co-authored 474 publications receiving 29885 citations. Previous affiliations of Derrick W. Crook include Oxford Brookes University & The Chinese University of Hong Kong.
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Journal ArticleDOI
Vaccine escape recombinants emerge after pneumococcal vaccination in the United States.
TL;DR: This is the first time a single recombinational event has been documented in vivo that resulted in both a change of serotype and penicillin nonsusceptibility, and has the potential to reduce PCV7 effectiveness in the longer term.
Journal ArticleDOI
Within-host evolution of bacterial pathogens
Xavier Didelot,A. Sarah Walker,Tim E. A. Peto,Derrick W. Crook,Derrick W. Crook,Daniel J. Wilson,Daniel J. Wilson +6 more
TL;DR: How whole-genome sequencing studies have advanced understanding of the mechanisms and principles of within-host genome evolution is described, and the consequences of findings such as a potent adaptive potential for pathogenicity are considered.
Journal ArticleDOI
Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK.
Koen B. Pouwels,Koen B. Pouwels,Emma Pritchard,Emma Pritchard,Philippa C Matthews,Philippa C Matthews,Philippa C Matthews,Nicole Stoesser,David W Eyre,Karina Doris Vihta,Karina Doris Vihta,Thomas House,Thomas House,Jodie Hay,John I. Bell,John N Newton,Jeremy Farrar,Derrick W. Crook,Duncan Cook,Emma Rourke,Ruth Studley,Tim E. A. Peto,Ian Diamond,A. Sarah Walker +23 more
TL;DR: The effectiveness of BNT162b2 and ChAdOx1 vaccines against new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections requires continuous reevaluation, given the increasingly dominant B.1.617.2 (Delta) variant.
Journal ArticleDOI
Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.
Caroline Allix-Béguec,Irena Arandjelovic,Lijun Bi,Patrick Beckert,Maryline Bonnet,Phelim Bradley,Andrea M. Cabibbe,Irving Cancino-Muñoz,Mark J. Caulfield,Angkana Chaiprasert,Daniela Maria Cirillo,David A. Clifton,Iñaki Comas,Derrick W. Crook,Maria Rosaria De Filippo,Han de Neeling,Roland Diel,Francis Drobniewski,Kiatichai Faksri,Maha R. Farhat,Joy Fleming,Philip W. Fowler,Tom Fowler,Qian Gao,Jennifer L. Gardy,Deborah Gascoyne-Binzi,Ana-Luiza Gibertoni-Cruz,Ana Gil-Brusola,Tanya Golubchik,Ximena Gonzalo,Louis Grandjean,Guangxue He,Jennifer L. Guthrie,Sarah Hoosdally,Martin Hunt,Zamin Iqbal,Nazir Ahmed Ismail,James C. Johnston,Faisal Masood Khanzada,Chiea Chuen Khor,Thomas Kohl,Clare Kong,Samuel Lipworth,Qingyun Liu,Gugu Maphalala,Elena Martinez,Vanessa Mathys,Matthias Merker,Paolo Miotto,Nerges Mistry,David Moore,Megan Murray,Stefan Niemann,Shaheed V. Omar,Rick T-H Ong,Tim E. A. Peto,James E. Posey,Therdsak Prammananan,Alexander S. Pym,Camilla Rodrigues,Mabel Rodrigues,Timothy C. Rodwell,Gian Maria Rossolini,Elisabeth Sánchez Padilla,Marco Schito,Xin Shen,Jay Shendure,Vitali Sintchenko,Alexander Sloutsky,E. Grace Smith,Matthew W. Snyder,Karine Soetaert,Angela M. Starks,Philip Supply,Prapat Suriyapol,Sabira Tahseen,Patrick Tang,Yik Ying Teo,Thuong N T Thuong,Guy E. Thwaites,Enrico Tortoli,Dick van Soolingen,A. Sarah Walker,Timothy M Walker,Mark H. Wilcox,Daniel J. Wilson,David H. Wyllie,Yang Yang,Hongtai Zhang,Yanlin Zhao,Baoli Zhu +90 more
TL;DR: Genotypic predictions of the susceptibility of M. tuberculosis to first‐line drugs were found to be correlated with phenotypic susceptibility to these drugs.
Journal ArticleDOI
Temporal and Geographic Stability of the Serogroup-Specific Invasive Disease Potential of Streptococcus pneumoniae in Children
Angela B. Brueggemann,Tim E. A. Peto,Derrick W. Crook,Jay C. Butler,Karl G. Kristinsson,Brian G. Spratt +5 more
TL;DR: There was a significant inverse correlation between invasive disease and carriage prevalence for the serotypes that were considered, which implies that the most invasive serotypes and serogroups were the least commonly carried and that the least frequently carried were the most likely to cause invasive disease.