D
Derrick W. Crook
Researcher at University of Oxford
Publications - 510
Citations - 38699
Derrick W. Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 92, co-authored 474 publications receiving 29885 citations. Previous affiliations of Derrick W. Crook include Oxford Brookes University & The Chinese University of Hong Kong.
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Journal ArticleDOI
Dynamics of MDR Enterobacter cloacae outbreaks in a neonatal unit in Nepal: insights using wider sampling frames and next-generation sequencing
Nicole Stoesser,Anna E. Sheppard,M. Shakya,B. Sthapit,Stephen Thorson,Adam Giess,Dominic F. Kelly,Andrew J. Pollard,Tim E. A. Peto,Anne-Sophie Walker,Derrick W. Crook +10 more
TL;DR: With whole-genome sequencing, the hypothesis that a cluster of 16 E. cloacae bacteraemia cases in a Nepali neonatal unit represented a single clonal outbreak was tested, using a wider set of epidemiologically unrelated clinical E. cloakae isolates for comparison.
Journal ArticleDOI
Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS
Bernadette C. Young,Sarah G Earle,Sona Soeng,Poda Sar,Varun Kumar,Songly Hor,Vuthy Sar,Rachel Bousfield,Nicholas D Sanderson,Leanne Barker,Nicole Stoesser,Katherine R. W. Emary,Christopher M. Parry,Christopher M. Parry,Emma K. Nickerson,Paul Turner,Paul Turner,Rory Bowden,Derrick W. Crook,David H. Wyllie,David H. Wyllie,Nicholas P. J. Day,Daniel J. Wilson,Daniel J. Wilson,Catrin E. Moore,Catrin E. Moore +25 more
TL;DR: Staphylococcal pyomyositis, like tetanus and diphtheria, is established as critically dependent on a single toxin and the potential for association studies to identify specific bacterial genes promoting severe human disease is demonstrated.
Journal ArticleDOI
Clostridium difficile Mixed Infection and Reinfection
David W Eyre,A. Sarah Walker,David Griffiths,Mark H. Wilcox,David H. Wyllie,Kate E. Dingle,Derrick W. Crook,Tim E. A. Peto +7 more
TL;DR: Isolates from consecutive Clostridium difficile infection (CDI) fecal samples underwent multilocus sequence typing and revealed mixed infections with >1 genotype, with odds of reinfection increased by 58% for every doubling of time between samples.
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Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex.
Ruth R. Miller,Ruth R. Miller,A. Sarah Walker,A. Sarah Walker,Heather Godwin,Heather Godwin,Rowena Fung,Rowena Fung,Antonina Votintseva,Rory Bowden,Rory Bowden,Rory Bowden,David Mant,Tim E. A. Peto,Tim E. A. Peto,Derrick W. Crook,Derrick W. Crook,Kyle Knox,Kyle Knox +18 more
TL;DR: Both transient and longer-term carriage exist; however, the approximately constant rates of S. aureus gain and loss suggest that ‘never’ or truly ‘persistent’ carriage are rare.
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Epidemiological studies of large resistance plasmids in Haemophilus
N. I. Leaves,Ioanna D. Dimopoulou,I. Hayes,Simon Kerridge,T. J. Falla,O. Secka,Richard A. Adegbola,Mary P. E. Slack,Tim E. A. Peto,Derrick W. Crook +9 more
TL;DR: Isolates with large plasmids occur at high frequency in the nasopharynx of the normal human population and consist of two populations in Hib, one associated with specific antibiotic resistance traits and the other cryptic, which do not appear to influence the invasiveness of Hib.