D
Didier Leys
Researcher at Heidelberg University
Publications - 8
Citations - 454
Didier Leys is an academic researcher from Heidelberg University. The author has contributed to research in topics: Stroke & Modified Rankin Scale. The author has an hindex of 5, co-authored 8 publications receiving 365 citations. Previous affiliations of Didier Leys include university of lille & University of Glasgow.
Papers
More filters
Journal ArticleDOI
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection
Stéphanie Debette,Yoichiro Kamatani,Tiina M. Metso,Manja Kloss,Ganesh Chauhan,Stefan T. Engelter,Alessandro Pezzini,Vincent Thijs,Hugh S. Markus,Martin Dichgans,Christiane Wolf,Ralf Dittrich,Emmanuel Touzé,Andrew M. Southerland,Yves Samson,Sherine Abboud,Yannick Béjot,Valeria Caso,Anna Bersano,Andreas Gschwendtner,Maria Sessa,John W. Cole,C. Lamy,Elisabeth De Bustos Medeiros,Simone Beretta,Leo H. Bonati,Armin J. Grau,Patrik Michel,Jennifer J. Majersik,Pankaj Sharma,Ludmila Kalashnikova,Maria Nazarova,L A Dobrynina,Eva Bartels,Benoit Guillon,Evita G. Van Den Herik,Israel Fernandez-Cadenas,Katarina Jood,Mike A. Nalls,Frank-Erik de Leeuw,Christina Jern,Yu-Ching Cheng,I. Werner,Antti J. Metso,Christoph Lichy,Philippe Lyrer,Tobias Brandt,Giorgio B. Boncoraglio,Heinz Erich Wichmann,Christian Gieger,Andrew D. Johnson,Thomas Böttcher,Maurizio Castellano,Dominique Arveiler,M. Arfan Ikram,Monique M.B. Breteler,Alessandro Padovani,James F. Meschia,Gregor Kuhlenbäumer,Arndt Rolfs,Bradford B. Worrall,Erich Bernd Ringelstein,Diana Zelenika,Turgut Tatlisumak,Mark Lathrop,Didier Leys,Philippe Amouyel,Jean Dallongeville,Jean Dallongeville,Jean Dallongeville +69 more
TL;DR: The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction, and the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions.
Journal ArticleDOI
Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes
Ilaria Maestrini,Daniel Strbian,Sophie Gautier,Elena Haapaniemi,Solène Moulin,Tiina Sairanen,Nelly Dequatre-Ponchelle,Gerli Sibolt,Charlotte Cordonnier,Susanna Melkas,Didier Leys,Turgut Tatlisumak,Régis Bordet +12 more
TL;DR: Higher neutrophil counts and NLR are independently associated with sICH and worse outcome at 3 months, and the identification of mediators of this effect could provide new targets for neuroprotection in patients treated by rtPA.
Journal ArticleDOI
Intravenous Thrombolysis in Patients Dependent on the Daily Help of Others Before Stroke
Henrik Gensicke,Daniel Strbian,Sanne M. Zinkstok,Jan F. Scheitz,Olivier Bill,Christian Hametner,Solène Moulin,Andrea Zini,Georg Kägi,Alessandro Pezzini,Visnja Padjen,Yannick Béjot,Sydney Corbiere,Thomas P. Zonneveld,David J. Seiffge,Yvo B. Roos,Christopher Traenka,Jukka Putaala,Nils Peters,Leo H. Bonati,Sami Curtze,Hebun Erdur,Gerli Sibolt,Peter M. Koch,Laura Vandelli,Peter Arthur Ringleb,Didier Leys,Charlotte Cordonnier,Patrik Michel,Christian H. Nolte,Philippe A. Lyrer,Turgut Tatlisumak,Paul J. Nederkoorn,Stefan T. Engelter +33 more
TL;DR: IVT-treated stroke patients who were dependent on the daily help of others before stroke carry a higher mortality risk than previously independent patients, and withholding IVT in previously dependent patients might not be justified.
Journal ArticleDOI
Door-to-needle time and the proportion of patients receiving intravenous thrombolysis in acute ischemic stroke: uniform interpretation and reporting.
Nyika D. Kruyt,Paul J. Nederkoorn,Martin Dennis,Didier Leys,Peter A. Ringleb,Anthony Rudd,Marinus Vermeulen,Jan Stam,Werner Hacke,Yvo B.W.E.M. Roos +9 more
TL;DR: A shorter delay from symptom to IVT, the so-called symptom-to-needle time, can make the difference between being independent and being dependent, and national guidelines recommend that the DNT should not exceed this 60-minute limit.
Journal ArticleDOI
Towards understanding seasonal variability in cervical artery dissection (CeAD).
Manja Kloss,A. J. Metso,Alessandro Pezzini,Didier Leys,Maurice Giroud,Tiina M. Metso,Turgut Tatlisumak,Christoph Lichy,Anna Bersano,Shérine Abboud,Armin J. Grau,Philippe Lyrer,Stéphanie Debette,Jean Dallongeville,Juan Jose Martin,V Caso,Caspar Grond-Ginsbach,Stefan T. Engelter +17 more
TL;DR: Higher pulse pressure was significantly associated with autumn–winter CeAD, while age, gender, history of hypertension, recent infection, and recent trauma were not, and no association between pulse pressure and seasonal occurrence was found in non-CeAD ischemic stroke patients.