Dwight L. A. Galam

TL;DR: It is demonstrated that subcutaneous adipose tissue of type 2 diabetics contains considerably more sphingolipids than non-diabetic, BMI-matched counterparts and that newly synthesized adipocyte sphingoipids are nutrient signals that drive changes in the adipose phenotype to influence whole-body energy expenditure and nutrient metabolism.

TL;DR: It is demonstrated that Mfsd2a is highly expressed in retinal pigment epithelium in embryonic eye, before the development of photoreceptors, and is the primary site of MfsD2a expression in the eye.

TL;DR: It is demonstrated that Mfsd2a is uniquely required postnatally at the blood-brain barrier for normal brain growth and DHA accretion, with DHA deficiency preceding the onset of microcephaly.

TL;DR: In this article , a cell-based screen was combined with biochemical, cell, and in vivo models to identify SPNS1, a previously orphaned transporter, as the transporter that mediates the rate-limiting lysosomal efflux of lysophospholipids for their recycling into cellular phospholipid pools.

TL;DR: In this article , the major facilitator superfamily domain containing 2a (Mfsd2a), a sodium-dependent lysophosphatidylcholine (LPC) transporter, is expressed at the apical surface of alveolar type 2 (AT2) cells.