M. Shabeer Yassin

TL;DR: It is demonstrated that subcutaneous adipose tissue of type 2 diabetics contains considerably more sphingolipids than non-diabetic, BMI-matched counterparts and that newly synthesized adipocyte sphingoipids are nutrient signals that drive changes in the adipose phenotype to influence whole-body energy expenditure and nutrient metabolism.

TL;DR: It is shown that macromolecular crowding facilitates brown adipocyte differentiation in adult human bone marrow mesenchymal stem cells (bmMSCs), as evidenced by substantially upregulating uncoupling protein 1 (UCP1) and uncoupled respiration and ‘browning’ in bmMSC-derived white adipocytes.

TL;DR: Differences indicate SGBS cells may help to identify mechanisms leading to browning, and inform the understanding for the use of SGBS vis-à-vis primary human subcutaneous adipocytes as a human white adipocyte model, guiding the selection of appropriate cell models in future metabolic research.

TL;DR: The first comprehensive expression profile of all known 27 human TRP genes in mesenchymal progenitors cells during white or brown adipogenesis is presented, showing TRPP3 and TRPM8 appear to be involved in the priming of mitochondria to perform uncoupled respiration downstream of adenylate cyclase.