S
Sandhya Sriram
Researcher at Agency for Science, Technology and Research
Publications - 16
Citations - 590
Sandhya Sriram is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Adipose tissue & Stem cell. The author has an hindex of 9, co-authored 15 publications receiving 500 citations. Previous affiliations of Sandhya Sriram include Nanyang Technological University.
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Journal ArticleDOI
Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB.
Sandhya Sriram,Subha Subramanian,Durgalakshmi Sathiakumar,Rithika Venkatesh,Mônica Senna Salerno,Craig McFarlane,Ravi Kambadur,Mridula Sharma +7 more
TL;DR: The results here show that myostatin (Mstn) is a pro‐oxidant and signals the generation of ROS in muscle cells through tumor necrosis factor‐α (TNF‐α) signaling via NF‐κB and NADPH oxidase and that inhibition of ROS induced by Mstn could lead to reduced muscle wasting during sarcopenia.
Journal ArticleDOI
Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.
Bhagirath Chaurasia,Vincent A. Kaddai,Graeme I. Lancaster,Darren C. Henstridge,Sandhya Sriram,Dwight L. A. Galam,Venkatesh Gopalan,K. N. Bhanu Prakash,S. Sendhil Velan,Sarada Bulchand,Teh Jing Tsong,Mei Wang,Monowarul Mobin Siddique,Guan Yuguang,Kristmundur Sigmundsson,Natalie A. Mellet,Jacquelyn M. Weir,Peter J. Meikle,M. Shabeer Yassin,Asim Shabbir,James A. Shayman,Yoshio Hirabayashi,Sue Anne Toh Ee Shiow,Shigeki Sugii,Scott A. Summers +24 more
TL;DR: It is demonstrated that subcutaneous adipose tissue of type 2 diabetics contains considerably more sphingolipids than non-diabetic, BMI-matched counterparts and that newly synthesized adipocyte sphingoipids are nutrient signals that drive changes in the adipose phenotype to influence whole-body energy expenditure and nutrient metabolism.
Journal ArticleDOI
Muscle-specific microRNA1 (miR1) targets heat shock protein 70 (HSP70) during Dexamethasone mediated atrophy
Himani Kukreti,Kottaiswamy Amuthavalli,Arigela Harikumar,Sushmitha Sathiyamoorthy,Peng Zhao Feng,Rengaraj Anantharaj,Suan Liang Kelvin Tan,Sudarsanareddy Lokireddy,Sabeera Bonala,Sandhya Sriram,Craig McFarlane,Ravi Kambadur,Mridula Sharma +12 more
TL;DR: A novel microRNA1 (miR1)-mediated mechanism through which Dex promotes skeletal muscle atrophy is shown, whereby Dex- and Mstn-mediated atrophic signals are integrated through miR1, which then either directly or indirectly, inhibits the proteins involved in providing protection against atrophy.
Journal ArticleDOI
Myostatin augments muscle-specific ring finger protein-1 expression through an NF-kB independent mechanism in SMAD3 null muscle
Sandhya Sriram,Subha Subramanian,Prasanna Kumar Juvvuna,Xiaojia Ge,Sudarsanareddy Lokireddy,Craig McFarlane,Walter Wahli,Ravi Kambadur,Mridula Sharma +8 more
TL;DR: It is shown that Smad3(-/-) mice have increased ROS levels in skeletal muscle, and inactivation of Mstn in these mice partially ablates the oxidative stress.
Journal ArticleDOI
Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells
Kosuke Takeda,Sandhya Sriram,Xin Hui Derryn Chan,Wee Kiat Ong,Chia Rou Yeo,Betty Tan,Seung-Ah Lee,Kien Voon Kong,Shawn Hoon,Hongfeng Jiang,Jason J. Yuen,Jayakumar Perumal,Madhur Agrawal,Candida Vaz,Jimmy Bok Yan So,Asim Shabbir,William S. Blaner,Malini Olivo,Weiping Han,Vivek Tanavde,Sue-Anne Toh,Shigeki Sugii,Shigeki Sugii +22 more
TL;DR: It is demonstrated that many genes involved in retinoic acid (RA) synthesis or regulated by RA are differentially expressed in human tissues and ASCs from subcutaneous and visceral fat.