E
Effie W. Petersdorf
Researcher at Fred Hutchinson Cancer Research Center
Publications - 242
Citations - 20326
Effie W. Petersdorf is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Transplantation & Human leukocyte antigen. The author has an hindex of 67, co-authored 234 publications receiving 18917 citations. Previous affiliations of Effie W. Petersdorf include University of Oxford & National Taiwan University.
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Journal ArticleDOI
Unrelated donor marrow transplantation for acute myeloid leukemia: an update of the Seattle experience
Jorge Sierra,Barry E. Storer,John A. Hansen,P.J. Martin,Effie W. Petersdorf,Ann E. Woolfrey,Dana C. Matthews,Jean E. Sanders,Rainer Storb,FR Appelbaum,Claudio Anasetti +10 more
TL;DR: Findings on the association between a high marrow cell dose and improved survival are extended and support the use of unrelated donor BMT for treatment of patients with high risk AML when a family match is not available.
Journal ArticleDOI
HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation.
Ann E. Woolfrey,John P. Klein,Michael Haagenson,Stephen R. Spellman,Effie W. Petersdorf,Machteld Oudshoorn,James Gajewski,Gregory A. Hale,John T. Horan,Minoo Battiwalla,Susana R. Marino,Michelle Setterholm,Olle Ringdén,Carolyn Katovich Hurley,Neal Flomenberg,Claudio Anasetti,Marcelo Fernandez-Vina,Stephanie J. Lee +17 more
TL;DR: HLA-C antigen-mismatched unrelated PBSC donors were associated with worse outcomes compared with 8/8 HLA-matched donors, and HLA mismatch was not associated with relapse or chronic GVHD.
Journal ArticleDOI
Hematopoietic Cell Transplantation as Curative Therapy for Idiopathic Myelofibrosis, Advanced Polycythemia Vera, and Essential Thrombocythemia
Daniella M. B. Kerbauy,Ted Gooley,George E. Sale,Mary E.D. Flowers,Kristine Doney,George E. Georges,Joanne E. Greene,Michael L. Linenberger,Effie W. Petersdorf,Brenda M. Sandmaier,Bart L. Scott,Mohamed L. Sorror,Derek L. Stirewalt,F. Marc Stewart,Robert P. Witherspoon,Rainer Storb,Frederick R. Appelbaum,H. Joachim Deeg +17 more
TL;DR: The findings show that hematopoietic cell transplantation offers potentially curative treatment for patients with ICMF, PV, or ET, and patients conditioned with targeted BU (plasma levels 800-900 ng/mL) plus cyclophosphamide (tBUCY) had a higher probability of survival than other patients.
Journal ArticleDOI
The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation.
Bronwen E. Shaw,Bronwen E. Shaw,Ted Gooley,Mari Malkki,J. Alejandro Madrigal,J. Alejandro Madrigal,Ann B. Begovich,Mary M. Horowitz,Alois Gratwohl,Olle Ringdén,Steven G.E. Marsh,Steven G.E. Marsh,Effie W. Petersdorf,Effie W. Petersdorf +13 more
TL;DR: The increased risk of GVHD associated with HLA-DPB1 mismatching is accompanied by a lower risk of relapse and knowledge of the DPB1 matching status prior to transplantation will aid in more precise risk stratification for the individual patient.
Journal ArticleDOI
Optimal HLA matching in hematopoietic cell transplantation.
TL;DR: Optizing the overall outcome of hematopoietic cell transplantation requires an appreciation for the relative importance of HLA factors with respect to other non-genetic factors that also influence transplant outcome.