E
Eirini P. Papapetrou
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 76
Citations - 8160
Eirini P. Papapetrou is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 25, co-authored 64 publications receiving 7010 citations. Previous affiliations of Eirini P. Papapetrou include University of Patras & Kettering University.
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Journal ArticleDOI
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Stuart M. Chambers,Christopher A. Fasano,Eirini P. Papapetrou,Mark J. Tomishima,Michel Sadelain,Lorenz Studer +5 more
TL;DR: Noggin/SB431542-based neural induction should facilitate the use of hES and hiPS cells in regenerative medicine and disease modeling and obviate the need for protocols based on stromal feeders or embryoid bodies.
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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
Gabsang Lee,Eirini P. Papapetrou,Hyesoo Kim,Stuart M. Chambers,Mark J. Tomishima,Christopher A. Fasano,Yosif Ganat,Jayanthi Menon,Fumiko Shimizu,Agnes Viale,Viviane Tabar,Michel Sadelain,Lorenz Studer +12 more
TL;DR: The derivation of patient-specific FD-iPSCs and the directed differentiation into cells of all three germ layers including peripheral neurons are reported, illustrating the promise of iPSC technology for gaining new insights into human disease pathogenesis and treatment.
Journal ArticleDOI
A bioinformatic assay for pluripotency in human cells
Franz-Josef Müller,Bernhard M. Schuldt,Roy Williams,Dylan Mason,Gulsah Altun,Eirini P. Papapetrou,Sandra Danner,Johanna E. Goldmann,Johanna E. Goldmann,Arne Herbst,Nils Ole Schmidt,Josef B. Aldenhoff,Louise C. Laurent,Louise C. Laurent,Jeanne F. Loring +14 more
TL;DR: PluriTest is reported, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles that allows for indirect methods such as differentiation into teratomas in immunodeficient mice.
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Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
Jr-Shiuan Yang,Thomas Maurin,Nicolas Robine,Kasper D. Rasmussen,Kate L. Jeffrey,Rohit Chandwani,Eirini P. Papapetrou,Michel Sadelain,Dónal O'Carroll,Eric C. Lai +9 more
TL;DR: It is shown that maturation of miR-451, a functional miRNA that is perfectly conserved among vertebrates, is independent of Dicer, and the mir-451 backbone is amenable to reprogramming, permitting vector-driven expression of diverse functional miRNAs in the absence of Dacer.
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Safe harbours for the integration of new DNA in the human genome
TL;DR: 'genomic safe harbours' are discussed — chromosomal locations where therapeutic transgenes can integrate and function in a predictable manner without perturbing endogenous gene activity and promoting cancer.