R
Roy Williams
Researcher at University of California, San Diego
Publications - 50
Citations - 4549
Roy Williams is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Gene & Promoter. The author has an hindex of 31, co-authored 49 publications receiving 4192 citations. Previous affiliations of Roy Williams include University of Birmingham & Centre national de la recherche scientifique.
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Journal ArticleDOI
The core meiotic transcriptome in budding yeasts
Michael Primig,Roy Williams,Roy Williams,Elizabeth A. Winzeler,Gela G. Tevzadze,Andrew R. Conway,Seung Y. Hwang,Ronald W. Davis,Rochelle Easton Esposito +8 more
TL;DR: High-density oligonucleotide microarrays were used to analyse the genomes and meiotic expression patterns of two yeast strains that display distinct kinetics and efficiencies of sporulation and yielded approximately 1,600 meiotically regulated genes in each strain.
Journal ArticleDOI
A bioinformatic assay for pluripotency in human cells
Franz-Josef Müller,Bernhard M. Schuldt,Roy Williams,Dylan Mason,Gulsah Altun,Eirini P. Papapetrou,Sandra Danner,Johanna E. Goldmann,Johanna E. Goldmann,Arne Herbst,Nils Ole Schmidt,Josef B. Aldenhoff,Louise C. Laurent,Louise C. Laurent,Jeanne F. Loring +14 more
TL;DR: PluriTest is reported, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles that allows for indirect methods such as differentiation into teratomas in immunodeficient mice.
Journal ArticleDOI
Regulatory networks define phenotypic classes of human stem cell lines
Franz-Josef Müller,Franz-Josef Müller,Louise C. Laurent,Louise C. Laurent,Dennis Kostka,Igor Ulitsky,Roy Williams,Christina Lu,In-Hyun Park,Mahendra S. Rao,Mahendra S. Rao,Ron Shamir,Philip H. Schwartz,Philip H. Schwartz,Nils Ole Schmidt,Jeanne F. Loring,Jeanne F. Loring +16 more
TL;DR: A database of global gene expression profiles that enables the classification of cultured human stem cells in the context of a wide variety of pluripotent, multipotent and differentiated cell types is created and analysis of this database offers a new strategy for classifying stem cells.
Journal ArticleDOI
S100A8/A9 activate key genes and pathways in colon tumor progression
TL;DR: Evidence is presented that S100A8/A9 interact with RAGE and carboxylated glycans on colon tumor cells and promote activation of MAPK and NF-κB signaling pathways, revealing a novel role for myeloid-derived S 100A8-A9 in activating specific downstream genes associated with tumorigenesis and in promoting tumor growth and metastasis.
Journal ArticleDOI
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
Jianfei Qi,Koh Nakayama,Robert D. Cardiff,Alexander D. Borowsky,Karen L. Kaul,Karen L. Kaul,Roy Williams,Stan Krajewski,Dan Mercola,Philip M. Carpenter,David D.L. Bowtell,Ze'ev Ronai +11 more
TL;DR: Tissue-specific expression of FoxA2 combined with Siah2-dependent HIF-1alpha availability enables a transcriptional program required for NE prostate tumor development and NE phenotype in PCa.