B
Bernhard M. Schuldt
Researcher at RWTH Aachen University
Publications - 10
Citations - 708
Bernhard M. Schuldt is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 6, co-authored 10 publications receiving 632 citations.
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Journal ArticleDOI
A bioinformatic assay for pluripotency in human cells
Franz-Josef Müller,Bernhard M. Schuldt,Roy Williams,Dylan Mason,Gulsah Altun,Eirini P. Papapetrou,Sandra Danner,Johanna E. Goldmann,Johanna E. Goldmann,Arne Herbst,Nils Ole Schmidt,Josef B. Aldenhoff,Louise C. Laurent,Louise C. Laurent,Jeanne F. Loring +14 more
TL;DR: PluriTest is reported, a robust open-access bioinformatic assay of pluripotency in human cells based on their gene expression profiles that allows for indirect methods such as differentiation into teratomas in immunodeficient mice.
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iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.
Athanasia D. Panopoulos,Matteo D’Antonio,Paola Benaglio,Roy Williams,Roy Williams,Sherin Hashem,Bernhard M. Schuldt,Christopher DeBoever,Angelo Arias,Melvin Garcia,Bradley C. Nelson,Olivier Harismendy,David Jakubosky,Margaret K.R. Donovan,William W. Greenwald,KathyJean Farnam,Megan Cook,Victor Borja,Carl A. Miller,Jonathan D. Grinstein,Frauke Drees,Jonathan Okubo,Kenneth E. Diffenderfer,Yuriko Hishida,Veronica Modesto,Carl T. Dargitz,Rachel Feiring,Chang Zhao,Aitor Aguirre,Thomas J. McGarry,Hiroko Matsui,He Li,Joaquin Reyna,Fangwen Rao,Daniel T. O'Connor,Gene W. Yeo,Sylvia M. Evans,Neil C. Chi,Kristen Jepsen,Naoki Nariai,Franz-Josef Müller,Lawrence S.B. Goldstein,Juan Carlos Izpisua Belmonte,Eric Adler,Jeanne F. Loring,W. Travis Berggren,Agnieszka D'Antonio-Chronowska,Erin N. Smith,Kelly A. Frazer +48 more
TL;DR: Using iPSCs from a family of individuals, it is shown that iPSC-derived cardiomyocytes demonstrate gene expression patterns that cluster by genetic background, and can be used to examine variants associated with physiological and disease phenotypes.
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Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells
Thomas F. Allison,Peter W. Andrews,Yishai Avior,Ivana Barbaric,Nissim Benvenisty,Christoph Bock,Jennifer L. Brehm,Oliver Bruestle,Ivan Damjanov,Andrew G. Elefanty,Daniel Felkner,Paul J. Gokhale,Florian Halbritter,Lyn Healy,Tim Xiaoming Hu,Barbara B. Knowles,Jeanne F. Loring,Tenneille Ludwig,Robyn Mayberry,Suzanne Jeanine Micallef,Jameelah Sheik Mohamed,Franz-Josef Mueller,Christine L. Mummery,Norio Nakatsuji,Elizabeth Ng,Steve Oh,Orla O'Shea,Martin F. Pera,Benjamin Reubinoff,Paul Robson,Janet Rossant,Bernhard M. Schuldt,Davor Solter,Koula Sourris,Glyn Stacey,Edouard G. Stanley,Hirofumi Suemori,Kazutoshi Takahashi,Shinya Yamanaka +38 more
TL;DR: EB assays, analyzed after differentiation under neutral conditions and under conditions promoting differentiation to ectoderm, mesoderm or endoderm lineages, are sufficient to assess the differentiation potential of PSCs, and only the teratoma assay offers evidence of malignant potential.
Journal ArticleDOI
PhysioSpace: Relating Gene Expression Experiments from Heterogeneous Sources Using Shared Physiological Processes
TL;DR: Using PhysioSpace with clinical cancer datasets reveals that such data exhibits large heterogeneity in the number of significant signature associations, indicating shared biological functionalities in disease associated processes.
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A guide to stem cell identification: progress and challenges in system-wide predictive testing with complex biomarkers
TL;DR: The challenges PluriTest and similar global assays need to address to fulfill their enormous potential for industrial, diagnostic and therapeutic applications are discussed.