Eric Stern

TL;DR: This work reports an approach that uses complementary metal oxide semiconductor (CMOS) field effect transistor compatible technology and hence demonstrates the specific label-free detection of below 100 femtomolar concentrations of antibodies as well as real-time monitoring of the cellular immune response.

TL;DR: The appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors are shown.

TL;DR: This work shows specific and quantitative detection of two model cancer antigens from a 10 uL sample of whole blood in less than 20 minutes and reduces its minimum required sensitivity by effectively pre-concentrating the biomarkers.

TL;DR: N nanoscale liposomal polymeric gels (nanolipogels; nLGs) of drug-complexed cyclodextrins and cytokine-encapsulating biodegradable polymers that can deliver small hydrophobic molecular inhibitors and water-soluble protein cytokines in a sustained fashion to the tumour microenvironment significantly delayed tumour growth and increased survival of tumour-bearing mice.

TL;DR: This study highlights the importance of sustained antigen release mediated by particulate platforms and its role in the long-term appearance of effector memory cellular response and compares the efficacy of Vesicular and solid biodegradable polymer platforms.