Importance of the Debye screening length on nanowire field effect transistor sensors.
TLDR
The appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors are shown.Abstract:
Nanowire field effect transistors (NW-FETs) can serve as ultrasensitive detectors for label-free reagents. The NW-FET sensing mechanism assumes a controlled modification in the local channel electric field created by the binding of charged molecules to the nanowire surface. Careful control of the solution Debye length is critical for unambiguous selective detection of macromolecules. Here we show the appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors.read more
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References
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Of Theory and Practice
TL;DR: The Essay concludes that practitioners theorize, and theorists practice, use these intellectual tools differently because the goals and orientations of theorists and practitioners, and the constraints under which they act, differ.
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Label-free immunodetection with CMOS-compatible semiconducting nanowires
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TL;DR: This work reports an approach that uses complementary metal oxide semiconductor (CMOS) field effect transistor compatible technology and hence demonstrates the specific label-free detection of below 100 femtomolar concentrations of antibodies as well as real-time monitoring of the cellular immune response.
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Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors
TL;DR: Two-terminal silicon nanowire electronic devices that function as ultrasensitive and selective detectors of DNA are reported that show that detection can be carried out to at least the tens of femtomolar range.
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Detection Limits for Nanoscale Biosensors
Paul E. Sheehan,Lloyd J. Whitman +1 more
TL;DR: The calculations reveal that reported femtomolar detection limits for biomolecular assays are very likely an analyte transport limitation, not a signal transduction limitation.