Jason Park

TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.

TL;DR: This work shows specific and quantitative detection of two model cancer antigens from a 10 uL sample of whole blood in less than 20 minutes and reduces its minimum required sensitivity by effectively pre-concentrating the biomarkers.

TL;DR: N nanoscale liposomal polymeric gels (nanolipogels; nLGs) of drug-complexed cyclodextrins and cytokine-encapsulating biodegradable polymers that can deliver small hydrophobic molecular inhibitors and water-soluble protein cytokines in a sustained fashion to the tumour microenvironment significantly delayed tumour growth and increased survival of tumour-bearing mice.

TL;DR: It is hypothesized that the efficacy of doxorubicin (DOX) can be maximized and dose-limiting cardiotoxicity minimized by controlled release from PEGylated nanoparticles.

TL;DR: This targeted nanoparticle approach is able to harness endogenous immune-regulatory pathways, providing a powerful new method to modulating T cell developmental plasticity in immune-mediated disease indications.