Eva Harris

TL;DR: Multiple lines of evidence indicate biannual peaks of ZIKV transmission in the region, likely driven by varying local environmental conditions for mosquito vectors and herd immunity and challenges arbovirus surveillance and disease control measures.

TL;DR: It is shown that DENV undergoes canonical cap-dependent translation initiation as well as a non-canonical mechanism when cap- dependent translation is suppressed, and an RNA hairpin structure in the capsid coding region (cHP) influences start codon selection and viral replication of the flavivirus dengue virus.

TL;DR: It is shown that surgically removing the site of DENV transmission in the skin after 4 hours rescued mice from disease in the absence of SGE, but no longer prevented lethal antibody-enhanced disease when SGE was present, indicating that SGE accelerates the dynamics of dengue pathogenesis after virus transmission inThe skin and induces severe antibody- enhanced disease systemically.

TL;DR: A country-specific expansion factor for dengue that allows for a more accurate estimate of incidence may aid governments and other institutions calculating disease burden, costs, resource needs for prevention and treatment, and the economic benefits of drug and vaccine development.

TL;DR: Evidence that supports a practical approach for dengue reduction through field release of wolbachia-infected mosquitoes is reviewed and a pragmatic approach to acquiring preliminary evidence of efficacy through various complementary methods is presented.