E
Eva Harris
Researcher at University of California, Berkeley
Publications - 357
Citations - 26475
Eva Harris is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 84, co-authored 332 publications receiving 22718 citations.
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Journal ArticleDOI
Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination
P. Robert Beatty,Henry Puerta-Guardo,Sarah S. Killingbeck,Dustin R. Glasner,Kaycie Hopkins,Eva Harris +5 more
TL;DR: The results of in vitro and in vivo experiments point to circulating dengue virus non-structural protein 1 (NS1) and the innate immune Toll-like receptor 4 (TLR4) as a focus for basic scientists as well as vaccine and drug developers.
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Murine Model for Dengue Virus-Induced Lethal Disease with Increased Vascular Permeability
TL;DR: Results demonstrate that D2S10 causes a more relevant disease in mice and that TNF-α may be one of several key mediators of severe DEN-induced disease in mouse, and it begins to provide mechanistic insights into DEN- induced disease in vivo.
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Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua.
Samantha N. Hammond,Angel Balmaseda,Leonel Pérez,Yolanda Tellez,Saira Saborio,Juan Carlos Mercado,Elsa Videa,Yoryelin Rodriguez,Maria Angeles Pérez,Ricardo Cuadra,Soraya Solano,Julio Rocha,Wendy Idiaquez,Alcides Gonzalez,Eva Harris +14 more
TL;DR: Age-related differences were identified in the prevalence of specific clinical manifestations as well as in their association with a confirmed DEN diagnosis of dengue virus infections in Nicaragua.
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Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness
Gayathri Manokaran,Esteban Finol,Esteban Finol,Chunling Wang,Jayantha Gunaratne,Jayantha Gunaratne,Justin Bahl,Eugenia Z. Ong,Hwee Cheng Tan,October M. Sessions,Alex M. Ward,Duane J. Gubler,Eva Harris,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco,Eng Eong Ooi,Eng Eong Ooi +17 more
TL;DR: These findings demonstrate a distinctive viral RNA–host protein interaction to evade the innate immune response for increased epidemiological fitness.
Journal ArticleDOI
Modulation of Dengue Virus Infection in Human Cells by Alpha, Beta, and Gamma Interferons
Michael S. Diamond,Michael S. Diamond,T. Guy Roberts,Dianna Edgil,Betty Lu,Joel D. Ernst,Joel D. Ernst,Eva Harris +7 more
TL;DR: Quantitative RT-PCR experiments indicate that IFN inhibits DV infection by preventing the accumulation of negative-strand viral RNA.