Eva Harris

TL;DR: Day-by-day analysis of clinical signs and symptoms together with longitudinal statistical analysis showed significant associations with testing dengue-positive and important differences during the early phase of illness compared to the entire course of illness.

TL;DR: The N207 glycosylation site is highly conserved among flaviviruses and is also essential for West Nile and Zika virus NS1 to trigger endothelial hyperpermeability via clathrin-mediated endocytosis, providing critical mechanistic insight into flavivirus NS1-induced pathogenesis.

TL;DR: A differential response of DEN2 to the mosquito and human cell cycle is demonstrated and analysis of viral RNA and protein released from the cells indicated that enhanced DEN2 assembly is largely responsible for increased virus titers produced during S-phase.

TL;DR: Results argue against a role for FcγRs in IgG transplacental transport, suggesting Fc engineering of maternally administered antibody to enhance only FcRn binding as a means to improve maternal-fetal transport of IgG.

TL;DR: To better understand the humoral responses and correlates of protection (CoP) induced by the VLP vaccine, evaluated VLP immunogenicity with and without alum in immune-competent mice and observed efficient induction of neutralizing antibody as well as a dose-sparing effect of alum.