Eva Harris

TL;DR: It is suggested that DCs play a key role in priming DENV-specific neutralizing or potentially harmful memory B- and T-cell responses, and that future DC-directed therapies may help induce protective memory responses and reduce dengue pathogenesis.

TL;DR: The first set of virologically confirmed homotypic DENV reinfections are described, which challenge the current understanding of DENV immunity and have important implications for modeling DENV transmission.

TL;DR: A rapid, specific, sensitive, and inexpensive method has been developed that detects RNA from a Zika virus strain associated with the current outbreak, and can also detect the African-lineage Zikairus strain using separate, specific primers.

TL;DR: It is demonstrated that EDIII-depleted human DENV-immune serum was protective against homologous DENV infection in vivo and could be replaced by neutralizing antibodies targeting other epitopes on the dengue virion.

TL;DR: The abundance of viral variants within a host, as well as the impact of viral mutations on amino acid encoding and predicted protein function, determined whether intrahost variants were observed at the interhost level in circulating Nicaraguan DENV-2 populations, strongly suggestive of purifying selection across transmission events.