Eva Harris

TL;DR: It is demonstrated that NS1 from dengue, Zika, West Nile, Japanese encephalitis, and yellow fever viruses selectively binds to and alters permeability of human endothelial cells from lung, dermis, umbilical vein, brain, and liver in vitro and causes tissue-specific vascular leakage in mice, reflecting the pathophysiology of each flavivirus.

TL;DR: Investigating the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons suggests that obesity may play an important role in influenza transmission.

TL;DR: It is demonstrated that time-dependent activation of the unfolded protein response by DENV-2 can override inhibition of translation, prevent apoptosis, and prolong the viral life cycle.

TL;DR: It is shown that differences in NS5 mediated binding and degradation between human and mouse STAT2 maps to a region within the STAT2 coiled-coil domain, and that overcoming this restriction through transgenic mouse technology may help in the development of a long-sought immune-competent mouse model of dengue virus infection.

TL;DR: The structure reveals the mechanism by which this potent and specific antibody blocks viral infection and shows that HMAb 1F4 can neutralize DENV at different stages of viral entry in a cell type and receptor dependent manner.