Eva Harris

TL;DR: The design of an internally controlled real-time reverse transcriptase PCR (rRT-PCR) that detects all four DENV serotypes but does not distinguish between them is reported, which is believed to serve to lengthen the period during which a confirmed molecular diagnosis of DENV infection can be provided.

TL;DR: Assessment of the memory B cell (MBC) and antibody response to Zika virus (ZIKV) in individuals with and without prior dengue virus (DENV) infection finds that ZIKV infection elicits a robust and specific MBC response that is only modestly affected by the number of prior DENV infections.

TL;DR: The single-reaction, multiplex format of the pan-DENV-CHIKV rRT-PCR, combined with sensitive detection of both viruses, has the potential to improve detection while decreasing testing costs and streamlining molecular workflow.

TL;DR: Interestingly, despite containing less symptoms that cannot be readily expressed by children aged less than 4 years, the revised case definition did not perform better in this age group, indicating that both case definitions have similar capacity to diagnose dengue.

TL;DR: Liposome-mediated delivery of NB-DNJ, in comparison with free NB- DNJ, resulted in a 3-log10 reduction in the dose of drug sufficient to enhance animal survival, which could liberate the therapeutic potential of many cytotoxic antivirals against both dengue virus and a wide array of other viruses.