F
F. Saverio Bersani
Researcher at University of California, San Francisco
Publications - 12
Citations - 903
F. Saverio Bersani is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Major depressive disorder & Mental health. The author has an hindex of 10, co-authored 12 publications receiving 628 citations. Previous affiliations of F. Saverio Bersani include University of Hertfordshire & Sapienza University of Rome.
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Journal ArticleDOI
Oxidative stress, inflammation and treatment response in major depression
Daniel Lindqvist,Daniel Lindqvist,Firdaus S. Dhabhar,S. Jill James,Christina M. Hough,Felipe A. Jain,F. Saverio Bersani,F. Saverio Bersani,Victor I. Reus,Josine E. Verhoeven,Josine E. Verhoeven,Elissa S. Epel,Laura Mahan,Rebecca Rosser,Owen M. Wolkowitz,Synthia H. Mellon +15 more
TL;DR: Investigating markers of inflammation and oxidative stress in unmedicated MDD subjects and controls found poorer antidepressant treatment response was related to higher baseline levels of the major oxidative stress marker, F2-isoprostanes, in vivo, and antidepressant response was associated with changes in oxidative (8-OHdG) and inflammatory (IL-6) markers.
Journal ArticleDOI
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Daniel Lindqvist,Elissa S. Epel,Synthia H. Mellon,Brenda W.J.H. Penninx,Dóra Révész,Josine E. Verhoeven,Victor I. Reus,Jue Lin,Laura Mahan,Christina M. Hough,Rebecca Rosser,F. Saverio Bersani,Elizabeth H. Blackburn,Owen M. Wolkowitz +13 more
TL;DR: A deeper understanding of cellular aging in psychiatric illnesses could lead to re-conceptualizing them as systemic illnesses with manifestations inside and outside the brain and could identify new treatment targets.
Journal ArticleDOI
Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.
Daniel Lindqvist,Daniel Lindqvist,Firdaus S. Dhabhar,Synthia H. Mellon,Rachel Yehuda,Rachel Yehuda,S. Marlene Grenon,S. Marlene Grenon,Janine D. Flory,Janine D. Flory,Linda M. Bierer,Linda M. Bierer,Duna Abu-Amara,Michelle Coy,Iouri Makotkine,Iouri Makotkine,Victor I. Reus,F. Saverio Bersani,Charles R. Marmar,Owen M. Wolkowitz +19 more
TL;DR: These findings strongly add to the growing literature suggesting that immune activation may be an important aspect of PTSD pathophysiology, although not directly correlated with current PTSD symptom levels in the PTSD group.
Journal ArticleDOI
Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder
Kelsey R. Dean,Rasha Hammamieh,Synthia H. Mellon,Duna Abu-Amara,Janine D. Flory,Janine D. Flory,Guia Guffanti,Kai Wang,Bernie J. Daigle,Aarti Gautam,Inyoul Lee,Ruoting Yang,Lynn M. Almli,F. Saverio Bersani,F. Saverio Bersani,Nabarun Chakraborty,Duncan E. Donohue,Kimberly Kerley,Taek Kyun Kim,Eugene M. Laska,Min Young Lee,Daniel Lindqvist,Daniel Lindqvist,Adriana Lori,Liangqun Lu,Burook Misganaw,Seid Muhie,Jennifer Newman,Nathan D. Price,Shizhen Qin,Victor I. Reus,Carole Siegel,Pramod R. Somvanshi,Gunjan S. Thakur,Yong Zhou,Leroy Hood,Kerry J. Ressler,Owen M. Wolkowitz,Rachel Yehuda,Rachel Yehuda,Marti Jett,Francis J. Doyle,Charles R. Marmar +42 more
TL;DR: The identification and validation of this diverse diagnostic panel represents a powerful and novel approach to improve accuracy and reduce bias in diagnosing combat-related PTSD.
Journal ArticleDOI
Metabolomic analysis of male combat veterans with post traumatic stress disorder.
Synthia H. Mellon,F. Saverio Bersani,Daniel Lindqvist,Rasha Hammamieh,Duncan E. Donohue,Kelsey R. Dean,Marti Jett,Rachel Yehuda,Janine D. Flory,Victor I. Reus,Linda M. Bierer,Iouri Makotkine,Duna Abu Amara,Clare Henn Haase,Michelle Coy,Francis J. Doyle,Charles R. Marmar,Owen M. Wolkowitz +17 more
TL;DR: Data show replicable, wide-ranging changes in the metabolic profile of combat-exposed males with PTSD, with a suggestion of mitochondrial alterations or dysfunction, that may contribute to the behavioral and somatic phenotypes associated with this disease.