F
Faruk Sheikh
Researcher at Center for Drug Evaluation and Research
Publications - 28
Citations - 4385
Faruk Sheikh is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Cytokine & Gene. The author has an hindex of 20, co-authored 27 publications receiving 4009 citations. Previous affiliations of Faruk Sheikh include Center for Biologics Evaluation and Research.
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Journal ArticleDOI
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Journal ArticleDOI
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Ludmila Prokunina-Olsson,Brian Muchmore,Wei Tang,Ruth M. Pfeiffer,Heiyoung Park,Harold Dickensheets,Dianna Hergott,Patricia Porter-Gill,Adam Mumy,Indu Kohaar,Sabrina Chen,Nathan Brand,McAnthony Tarway,Luyang Liu,Faruk Sheikh,Jacquie Astemborski,Herbert L. Bonkovsky,Brian R. Edlin,Brian R. Edlin,Charles D. Howell,Timothy R. Morgan,Timothy R. Morgan,David L. Thomas,Barbara Rehermann,Raymond P. Donnelly,Thomas R. O'Brien +25 more
TL;DR: RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA to mimic HCV infection provides new insights into the genetic regulation of HCV clearance and its clinical management.
Journal ArticleDOI
The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
TL;DR: The receptors for these cytokines are often present on cell lines derived from various tumors, including liver, colorectal, and pancreatic carcinomas, and may provide novel targets for inhibiting the growth of certain types of cancer.
Journal ArticleDOI
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
Thirumalai R. Ramalingam,John T. Pesce,Faruk Sheikh,Allen W. Cheever,Margaret M. Mentink-Kane,Mark S. Wilson,Sean Stevens,David M. Valenzuela,Andrew J. Murphy,George D. Yancopoulos,Joseph F. Urban,Raymond P. Donnelly,Thomas A. Wynn +12 more
TL;DR: Type I and II IL-4 receptors exert distinct effects on immune responses, and Il13ra1−/− mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis.
Journal ArticleDOI
Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
Faruk Sheikh,Vitaliy V. Baurin,Anita Lewis-Antes,Nital K. Shah,Sergey V. Smirnov,Shubha Anantha,Harold Dickensheets,Laure Dumoutier,Jean-Christophe Renauld,Alexander Zdanov,Raymond P. Donnelly,Sergei V. Kotenko +11 more
TL;DR: It is demonstrated that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2, demonstrating that this receptor combination is unique and specific forIL-26.