P
Patricia Porter-Gill
Researcher at National Institutes of Health
Publications - 37
Citations - 1805
Patricia Porter-Gill is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Single-nucleotide polymorphism & Bladder cancer. The author has an hindex of 15, co-authored 33 publications receiving 1654 citations. Previous affiliations of Patricia Porter-Gill include University of Cincinnati & University of Utah.
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Journal ArticleDOI
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Ludmila Prokunina-Olsson,Brian Muchmore,Wei Tang,Ruth M. Pfeiffer,Heiyoung Park,Harold Dickensheets,Dianna Hergott,Patricia Porter-Gill,Adam Mumy,Indu Kohaar,Sabrina Chen,Nathan Brand,McAnthony Tarway,Luyang Liu,Faruk Sheikh,Jacquie Astemborski,Herbert L. Bonkovsky,Brian R. Edlin,Brian R. Edlin,Charles D. Howell,Timothy R. Morgan,Timothy R. Morgan,David L. Thomas,Barbara Rehermann,Raymond P. Donnelly,Thomas R. O'Brien +25 more
TL;DR: RNA sequencing in primary human hepatocytes activated with synthetic double-stranded RNA to mimic HCV infection provides new insights into the genetic regulation of HCV clearance and its clinical management.
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Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma
Lavanya H. Palavalli,Todd D. Prickett,John R. Wunderlich,Xiaomu Wei,Allison S. Burrell,Patricia Porter-Gill,Sean Davis,Chenwei Wang,Julia C. Cronin,Neena S Agrawal,Jimmy Lin,Wendy Westbroek,Shelley Hoogstraten-Miller,Alfredo A. Molinolo,Patricia Fetsch,Armando C. Filie,Michael P. O'Connell,Carolyn E. Banister,Jason D. Howard,Phillip Buckhaults,Ashani T. Weeraratna,Lawrence C. Brody,Steven A. Rosenberg,Yardena Samuels +23 more
TL;DR: expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild- type MMP-8 has the ability to inhibit melanoma progression.
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A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.
Kerstin B. Meyer,Ana-Teresa Maia,Martin O'Reilly,Maya Ghoussaini,Radhika Prathalingam,Patricia Porter-Gill,Stefan Ambs,Ludmila Prokunina-Olsson,Jason S. Carroll,Bruce A.J. Ponder +9 more
TL;DR: A new functional prostate cancer risk variant at the 8q24 locus, rs378854 allele G, that reduces binding of the YY1 protein and is associated with increased expression of PVT1 located 0.5 Mb downstream.
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Evaluation of a 7-Day Continuous Intravenous Infusion of Decitabine: Inhibition of Promoter-Specific and Global Genomic DNA Methylation
Wolfram E. Samlowski,Sancy A. Leachman,Mark Wade,Pamela B. Cassidy,Patricia Porter-Gill,Leslie T. Busby,Richard H. Wheeler,Kenneth M. Boucher,Frank A. Fitzpatrick,David A. Jones,Adam R. Karpf +10 more
TL;DR: A 168-hour continuous infusion of decitabine is well tolerated and results in the inhibition of promoter-specific and genomic DNA methylation in vivo.
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Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
Yi-Ping Fu,Indu Kohaar,Nathaniel Rothman,Julie Earl,Jonine D. Figueroa,Yuanqing Ye,Núria Malats,Wei Tang,Luyang Liu,Montserrat Garcia-Closas,Brian Muchmore,Nilanjan Chatterjee,Mc Anthony Tarway,Manolis Kogevinas,Patricia Porter-Gill,Dalsu Baris,Adam Mumy,Demetrius Albanes,Mark P. Purdue,Amy Hutchinson,Alfredo Carrato,Adonina Tardón,Consol Serra,Reina García-Closas,Josep Lloreta,Alison Johnson,Molly Schwenn,Margaret R. Karagas,Alan R. Schned,W. Ryan Diver,Susan M. Gapstur,Michael J. Thun,Jarmo Virtamo,Stephen J. Chanock,Joseph F. Fraumeni,Debra T. Silverman,Xifeng Wu,Francisco X. Real,Francisco X. Real,Ludmila Prokunina-Olsson +39 more
TL;DR: A joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors.