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Mingjun Bi
Researcher at University of Texas Health Science Center at San Antonio
Publications - 7
Citations - 265
Mingjun Bi is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Enhancer & Enhancer RNAs. The author has an hindex of 3, co-authored 6 publications receiving 76 citations. Previous affiliations of Mingjun Bi include University of Texas at San Antonio.
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Journal ArticleDOI
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Joo-Hyung Lee,Ruoyu Wang,Ruoyu Wang,Feng Xiong,Joanna Krakowiak,Zian Liao,Zian Liao,Phuoc T. Nguyen,Phuoc T. Nguyen,Elena V. Moroz-Omori,Jiaofang Shao,Xiaoyu Zhu,Michael J. Bolt,Haoyi Wu,Haoyi Wu,Pankaj Singh,Mingjun Bi,Caleb J. Shi,Naadir Jamal,Guojie Li,Ragini Mistry,Sung Yun Jung,Kuang-Lei Tsai,Josephine C. Ferreon,Fabio Stossi,Amedeo Caflisch,Zhijie Liu,Michael A. Mancini,Wenbo Li,Wenbo Li +29 more
TL;DR: In this article, a high sensitivity method methylation-inscribed nascent transcripts sequencing (MINT-seq) was used to characterize the landscapes of N6-methyladenosine (m6A) on nascent RNAs.
Journal ArticleDOI
A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer.
Chi Zhu,Li Li,Zhao Zhang,Mingjun Bi,Hu Wang,Wenyue Su,Karen Hernandez,Pingping Liu,Junqiang Chen,Junqiang Chen,Mingqiu Chen,Mingqiu Chen,Tim H M Huang,Lizhen Chen,Zhijie Liu +14 more
TL;DR: The data reveal a non-canonical function of YAP1 and TEAD4 as ERα cofactors in regulating cancer growth, highlighting the potential of Yap/TEAD as possible actionable drug targets for ERα+ breast cancer.
Journal ArticleDOI
Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance.
Mingjun Bi,Zhao Zhang,Yi-Zhou Jiang,Pengya Xue,Hu Wang,Zhao Lai,Xiaoyong Fu,Carmine De Angelis,Yue Gong,Zhen Gao,Jianhua Ruan,Jianhua Ruan,Victor X. Jin,Elisabetta Marangoni,Elodie Montaudon,Christopher K. Glass,Wei Li,Tim H M Huang,Zhi Ming Shao,Rachel Schiff,Lizhen Chen,Zhijie Liu +21 more
TL;DR: This study suggests that differential high-order assemblies of transcription factors on enhancers trigger genome-wide enhancer reprogramming, resulting in transcriptional transitions that promote tumour phenotypic plasticity and therapy resistance.
Journal ArticleDOI
Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor.
Mei Yang,Ji Hoon Lee,Zhao Zhang,Richard De La Rosa,Mingjun Bi,Yuliang Tan,Yiji Liao,Juyeong Hong,Baowen Du,Yanming Wu,Jessica Scheirer,Tao Hong,Tao Hong,Wei Li,Wei Li,Teng Fei,Chen-Lin Hsieh,Zhijie Liu,Wenbo Li,Wenbo Li,Michael G. Rosenfeld,Kexin Xu +21 more
TL;DR: This work demonstrates a complete mechanism underlying the action of eRNAs in modulating and refining the locus-specific transcriptional program.
Journal ArticleDOI
Epigenomics-based identification of oestrogen-regulated long noncoding RNAs in ER+ breast cancer
Zhao Zhang,Wei Yu,Wei Yu,Dan Tang,Dan Tang,Yufan Zhou,Mingjun Bi,Hu Wang,Yan Zheng,Mingqiu Chen,Li Li,Xinping Xu,Wei Zhang,Huimin Tao,Victor X. Jin,Zhijie Liu,Lizhen Chen +16 more
TL;DR: 3D chromatin architecture analyses suggest that oestrogen-regulated lncRNAs and their neighbouring E2-resonsive coding genes, exemplified by LINC00160 and RUNX1, might be regulated as a 3D structural unit resulted from enhancer-promoter interactions.