F
Frances Rocamora
Researcher at University of California, San Diego
Publications - 7
Citations - 201
Frances Rocamora is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Plasmodium falciparum & Artemisinin. The author has an hindex of 3, co-authored 7 publications receiving 123 citations. Previous affiliations of Frances Rocamora include Nanyang Technological University.
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Journal ArticleDOI
Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.
Frances Rocamora,Lei Zhu,Kek-Yee Liong,Arjen M. Dondorp,Olivo Miotto,Sachel Mok,Zbynek Bozdech +6 more
TL;DR: A functional in vitro model of artemisinin resistance is presented that is underlined by a new set of genetic polymorphisms as potential genetic markers that could play a role in regulating art Artemisinin response in natural infections.
Journal ArticleDOI
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.
Lei Zhu,Jaishree Tripathi,Frances Rocamora,Olivo Miotto,Rob W. van der Pluijm,Rob W. van der Pluijm,Till S. Voss,Till S. Voss,Sachel Mok,Dominic P. Kwiatkowski,François Nosten,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White,Arjen M. Dondorp,Arjen M. Dondorp,Zbynek Bozdech +17 more
TL;DR: Two genetic and physiological backgrounds associating with artemisinin resistance in the GMS are identified, together with a farnesyltransferase protein and a thioredoxin-like protein which may act as vital intermediators linking the Pfk13 C580Y mutation to the prolonged parasite clearance time.
Journal ArticleDOI
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
Gregory LaMonte,Frances Rocamora,Danushka S. Marapana,Danushka S. Marapana,Nina F. Gnädig,Sabine Ottilie,Madeline R. Luth,Tilla S. Worgall,Gregory M. Goldgof,Gregory M. Goldgof,Roxanne Mohunlal,Roxanne Mohunlal,T. R. Santha Kumar,Jennifer K. Thompson,Jennifer K. Thompson,Edgar Vigil,Jennifer A. Yang,Dylan Hutson,Trevor Johnson,Jianbo Huang,Roy Williams,Bing Yu Zou,Andrea L. Cheung,Prianka Kumar,Timothy J. Egan,Marcus C. S. Lee,Dionicio Siegel,Alan F. Cowman,Alan F. Cowman,David A. Fidock,Elizabeth A. Winzeler +30 more
TL;DR: It is shown that IZP-resistant S. cerevisiae clones carry mutations in genes involved in Endoplasmic Reticulum (ER)-based lipid homeostasis and autophagy, which highlights a mechanism for blocking parasite development that is distinct from those of standard compounds used to treat malaria.
Journal ArticleDOI
PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum
Frances Rocamora,Purva Gupta,Purva Gupta,Eva S. Istvan,Madeline R. Luth,Emma F. Carpenter,Krittikorn Kümpornsin,Erika Sasaki,Jaeson Calla,Nimisha Mittal,Krypton Carolino,Edward Owen,Manuel Llinás,Sabine Ottilie,Daniel E. Goldberg,Marcus C. S. Lee,Elizabeth A. Winzeler +16 more
TL;DR: In malaria, chemical genetics is a powerful method for assigning function to uncharacterized genes as discussed by the authors, and chemical genetics can be used to assign function to genes in uncharacterised genes.
Journal ArticleDOI
Genomic Approaches to Drug Resistance in Malaria.
TL;DR: A broad overview of common genomic approaches that have been used to discover the alleles that drive drug response phenotypes in the most lethal human malaria parasite is provided.