F
Francis R. Carbone
Researcher at University of Melbourne
Publications - 216
Citations - 37352
Francis R. Carbone is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 83, co-authored 213 publications receiving 35098 citations. Previous affiliations of Francis R. Carbone include Cooperative Research Centre & Washington University in St. Louis.
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Journal ArticleDOI
T cell receptor antagonist peptides induce positive selection
Kristin A. Hogquist,Stephen C. Jameson,William R. Heath,Jane L Howard,Michael J. Bevan,Francis R. Carbone +5 more
TL;DR: Results show that the process of positive selection is exquisitely peptide specific and sensitive to extremely low ligand density and support the notion that low efficacy ligands mediate positive selection.
Journal ArticleDOI
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Sally R.M. Bennett,Sally R.M. Bennett,Francis R. Carbone,Freda Karamalis,Freda Karamalis,Richard A. Flavell,Jacques F. A. P. Miller,William R. Heath +7 more
TL;DR: It is shown that signalling through CD40 on the antigen-presenting cells can replace the requirement for TH cells, indicating that T-cell ‘help’, at least for generation of CTLs by cross-priming, is mediated by signalling throughCD40 onThe antigen- presenting cell.
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Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
TL;DR: Results show that successful generation of MHC class II‐restricted, OVA‐specific αβTCR transgenic mice was dependent upon combining cDNA‐ and genomic DNA‐based constructs for expression of the respective α‐ and β‐chains of the TCR.
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Introduction of soluble protein into the class I pathway of antigen processing and presentation
TL;DR: C57BL/6 mice immunized against a syngeneic tumor cell transfected with chicken ovalbumin cDNA gave rise to H-2Kb-restricted CTL specific for the OVA258-276 peptide, which was able to target H- 2b cells for lysis by the CTL in a 3 hr assay.
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Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
Thomas Gebhardt,Linda M. Wakim,Liv Eidsmo,Patrick C. Reading,William R. Heath,Francis R. Carbone +5 more
TL;DR: A unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia is described, representing an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.