F
Frank Baas
Researcher at Leiden University Medical Center
Publications - 446
Citations - 33815
Frank Baas is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Gene & Complement system. The author has an hindex of 93, co-authored 434 publications receiving 31187 citations. Previous affiliations of Frank Baas include Flanders Institute for Biotechnology & Academic Medical Center.
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Journal Article
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
Marcel Kool,M. De Haas,George L. Scheffer,R.J. Scheper,M. J. T. Van Eijk,J. A. Juijn,Frank Baas,Piet Borst +7 more
TL;DR: In this paper, the authors identified three new homologues of MRP1, the gene encoding the multidrug resistanceassociated protein, and cMOAT (or MRP2 ), the canalicular multispecific organic anion transporter gene.
Journal ArticleDOI
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Elizabeth T. Cirulli,Brittany N. Lasseigne,Slavé Petrovski,Peter C. Sapp,Patrick A. Dion,Claire S. Leblond,Julien Couthouis,Yi-Fan Lu,Quanli Wang,Brian J. Krueger,Zhong-fa Ren,Jonathan E. M. Keebler,Yujun Han,Shawn Levy,Braden E. Boone,Jack R. Wimbish,Lindsay L. Waite,Angela Jones,John P. Carulli,Aaron G. Day-Williams,John F. Staropoli,Winnie Xin,Alessandra Chesi,Alya R. Raphael,Diane McKenna-Yasek,Janet Cady,J. M. B. Vianney de Jong,Kevin P. Kenna,Bradley N. Smith,Simon Topp,Jack W. Miller,Athina-Soragia Gkazi,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink,Vincenzo Silani,Nicola Ticozzi,Christopher Shaw,Robert H. Baloh,Stanley H. Appel,Ericka Simpson,Clotilde Lagier-Tourenne,Stefan M. Pulst,Summer Gibson,John Q. Trojanowski,Lauren Elman,Leo McCluskey,Murray Grossman,Neil A. Shneider,Wendy K. Chung,John Ravits,Jonathan D. Glass,Katherine B. Sims,Vivianna M. Van Deerlin,Tom Maniatis,Sebastian D. Hayes,Alban Ordureau,Sharan Swarup,John Landers,Frank Baas,Andrew S. Allen,Richard Bedlack,J. Wade Harper,Aaron D. Gitler,Guy A. Rouleau,Robert H. Brown,Matthew B. Harms,Gregory M. Cooper,Tim Harris,Richard M. Myers,David Goldstein +70 more
TL;DR: A moderate-scale sequencing study aimed at increasing the number of genes known to contribute to predisposition for ALS found several known ALS genes were found to be associated, and TBK1 (the gene encoding TANK-binding kinase 1) was identified as an ALS gene.
Journal ArticleDOI
The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains
Huib N. Caron,Barbera D. C. van Schaik,Merlijn van der Mee,Frank Baas,Gregory J. Riggins,Peter van Sluis,Marie-Christine Hermus,Ronald van Asperen,Kathy Boon,P.A. Voûte,S. H. Heisterkamp,Antoine H. C. van Kampen,Rogier Versteeg +12 more
TL;DR: The Human Transcriptome Map (HPM) as mentioned in this paper is a tool to search for genes that are overexpressed or silenced in cancer using the SAGE serial analysis of gene expression.
Journal ArticleDOI
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
G. J. R. Zaman,M. J. Flens,M. R. Van Leusden,M. De Haas,H.S. Mülder,Jan Lankelma,Herbert M. Pinedo,Rik J. Scheper,Frank Baas,H. J. Broxterman,Piet Borst +10 more
TL;DR: It is concluded that MRP is a plasma membrane drug-efflux pump that confers drug resistance in human lung carcinoma cells by generating a subline stably transfected with an expression vector containing MRP cDNA.
Journal ArticleDOI
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.
Raymond Evers,Marcel Kool,L. Van Deemter,Hans Janssen,J. Calafat,L. C. J. M. Oomen,Coen C. Paulusma,R.P.J. Oude Elferink,Frank Baas,A.H. Schinkel,Piet Borst +10 more
TL;DR: It is shown that cMOAT causes transport of the organic anions S-(2,4-dinitrophenyl)-glutathione, the glutathione conjugate of ethacrynic acid, and S-(PGA1)-gluten, a substrate not shown to be transported by organic anion transporters previously.