Garry P. Nolan

TL;DR: In this article, a method of generating a high resolution two-dimensional image of a sample comprising cells and extracellular structures is provided, which includes labeling a sample with at least one mass tag, thereby producing a labeled sample; scanning the sample with a secondary ion mass spectrometer (SIMS) ion beam to generate a data set that comprises spatially-addressable measurements of the abundance of the mass tag across an area of the sample; and outputting the data set.

TL;DR: In this article, the authors report the design, development, optimization, and application of a 56-marker CODEX antibody panel to eight cutaneous T cell lymphoma (CTCL) patient samples.

TL;DR: The results suggest that women predisposed to preterm birth may be prone to mount an exacerbated TLR4 response during the course of pregnancy, suggesting the power of single‐cell mass cytometry to detect biologically important differences in a relatively small patient cohort.

TL;DR: CytoSPADE is a high-performance implementation of an interface for the Spanning-tree Progression Analysis of Density-normalized Events algorithm for tree-based analysis and visualization of this high-dimensional cytometry data.

TL;DR: The construction of a murine angiostatin–endostatin fusion gene (Statin-AE) is reported which shows enhanced antiangiogenic activity on human umbilical vein endothelial cell (HUVEC) tube formation in vitro compared with angiOSTatin or endostatin alone.