Garry P. Nolan

TL;DR: In this article, high-definition multiplex ion beam imaging (HD-MIBI) was used to estimate the subcellular distribution of the chemotherapy drug cisplatin in cells.

TL;DR: PANINI as mentioned in this paper was proposed to simultaneously quantify DNA, RNA, and protein levels within these tissue compartments and enabled the spatial dissection of cellular phenotypes, functional markers, and viral events resulting from infection.

TL;DR: Data establish a direct link between the loss of TERT activity, telomere shortening and defective erythropoiesis and suggest that novel strategies to restore telomerase function may have an important role in the treatment of the resulting anemia.

TL;DR: The mechanism underlying the synergy between signaling by the cytokine interleukin-2 (IL-2) and subsequent stimulation of the activating receptor NKG2D in immature and mature subsets of human NK cells is delineated and the mathematical framework can be used to glean mechanisms underlying synergistic signaling pathways in other activated immune cells.

TL;DR: Two retroviral vector-based recombination substrate systems designed to assay for lymphoid VDJ recombinase activity in cultured cells incorporate a constitutive dominant marker gene to allow selection of cells that stably integrate the substrate.