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Garry P. Nolan
Researcher at Stanford University
Publications - 519
Citations - 54521
Garry P. Nolan is an academic researcher from Stanford University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 104, co-authored 474 publications receiving 46025 citations. Previous affiliations of Garry P. Nolan include Massachusetts Institute of Technology & New York University.
Papers
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Journal ArticleDOI
Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus
William E. O'Gorman,Elena W Y Hsieh,Erica S. Savig,Pier Federico Gherardini,Joseph D. Hernandez,Leo Hansmann,Imelda Balboni,Paul J. Utz,Sean C. Bendall,Wendy J. Fantl,David B. Lewis,Garry P. Nolan,Mark M. Davis,Mark M. Davis +13 more
TL;DR: Mass cytometry defined a systems-level reference framework for human TLR activation, which can be applied to study perturbations in patients with inflammatory diseases, such as SLE.
Journal ArticleDOI
Evolution of peptides that modulate the spectral qualities of bound, small-molecule fluorophores
TL;DR: Proof of principle, fluorophore dye binding peptides that could have applications in fluorescent dye-based approaches in vitro and in vivo are created and could readily be selected that could bind to small-molecule fluorophores.
Patent
Methods and compositions for detecting receptor-ligand interactions in single cells
Omar D. Perez,Garry P. Nolan +1 more
TL;DR: In this article, the authors provide methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry, which can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state.
Journal ArticleDOI
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line.
Yapeng Su,Yapeng Su,Melissa E. Ko,Hanjun Cheng,Ronghui Zhu,Min Xue,Min Xue,Jessica Wang,Jihoon W. Lee,Luke Frankiw,Alexander M. Xu,Stephanie Wong,Lidia Robert,Kaitlyn Takata,Dan Yuan,Yue Lu,Sui Huang,Antoni Ribas,Raphael D. Levine,Raphael D. Levine,Garry P. Nolan,Wei Wei,Wei Wei,Sylvia K. Plevritis,Guideng Li,David Baltimore,James R. Heath +26 more
TL;DR: It is uncovered that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition, thus updating the paradigm of adaptive resistance development in an isogenic cell population.
Journal ArticleDOI
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells
TL;DR: A novel, specific functional consequence of L FA-1-mediated cytolytic activity in perforin-containing human NK subsets is identified, demonstrating LFA-1 could regulate degranulation mechanisms.