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Geertje van Keulen
Researcher at Swansea University
Publications - 25
Citations - 827
Geertje van Keulen is an academic researcher from Swansea University. The author has contributed to research in topics: Streptomyces coelicolor & Binding site. The author has an hindex of 13, co-authored 23 publications receiving 743 citations. Previous affiliations of Geertje van Keulen include John Innes Centre & University of Groningen.
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Journal ArticleDOI
Antibiotic Overproduction in Streptomyces coelicolor A3(2) Mediated by Phosphofructokinase Deletion
Irina Borodina,Jeroen Siebring,Jie Zhang,Colin P. Smith,Geertje van Keulen,Lubbert Dijkhuizen,Jens Nielsen +6 more
TL;DR: High level production of antibiotics in streptomycetes requires engineering of the primary metabolism, and targeting a key enzyme in glycolysis, phosphofructokinase, leads to improved antibiotic production in Streptomyces coelicolor A3(2).
Journal ArticleDOI
Back to the future of soil metagenomics
Joseph Nesme,Wafa Achouak,Spiros N. Agathos,Spiros N. Agathos,Mark J. Bailey,Petr Baldrian,Dominique Brunel,Åsa Frostegård,Thierry Heulin,Janet K. Jansson,Edouard Jurkevitch,Kristiina Kruus,George A. Kowalchuk,Antonio Lagares,Hilary M. Lappin-Scott,Philippe Lemanceau,Denis Le Paslier,Ines Mandic-Mulec,J. Colin Murrell,David D. Myrold,Renaud Nalin,Paolo Nannipieri,Josh D. Neufeld,Fergal O'Gara,Fergal O'Gara,John J. Parnell,Alfred Pühler,Victor Satler Pylro,Juan L. Ramos,Luiz Fernando Wurdig Roesch,Michael Schloter,Christa Schleper,Alexander Sczyrba,Angela Sessitsch,Sara Sjöling,Jan Tind Sørensen,Søren J. Sørensen,Christoph C. Tebbe,Edward Topp,George Tsiamis,Jan Dirk van Elsas,Geertje van Keulen,Franco Widmer,Michael Wagner,Tong Zhang,Xiaojun Zhang,Liping Zhao,Yong-Guan Zhu,Timothy M Vogel,Pascal Simonet +49 more
TL;DR: The ability to explore soil microbial communities with increasing capacity offers the highest promise for answering many outstanding who, what, where, when, why, and with whom questions such as: Which microorganisms are linked to which soil habitats?
Journal ArticleDOI
Two novel homologous proteins of Streptomyces coelicolor and Streptomyces lividans are involved in the formation of the rodlet layer and mediate attachment to a hydrophobic surface
Dennis Claessen,Han A. B. Wösten,Geertje van Keulen,Onno G. Faber,Alexandra M.C.R. Alves,Wim G. Meijer,Lubbert Dijkhuizen +6 more
TL;DR: Sequences homologous to rdlA and rdlB occur in a number of streptomycetes representing the phylogenetic diversity of this group of bacteria, indicating a general role for these proteins in rodlet formation and attachment.
Journal ArticleDOI
Analysis of DNA Binding and Transcriptional Activation by the LysR-Type Transcriptional Regulator CbbR of Xanthobacter flavus
TL;DR: The LysR-type transcriptional regulator CbbR controls the expression of the cbb and gap-pgk operons in Xanthobacter flavus, which encode the majority of the enzymes of the Calvin cycle required for autotrophic CO2 fixation.
Book ChapterDOI
Production of specialized metabolites by Streptomyces coelicolor A3(2).
Geertje van Keulen,Paul Dyson +1 more
TL;DR: This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.