G
Georg Zeller
Researcher at European Bioinformatics Institute
Publications - 95
Citations - 14859
Georg Zeller is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 39, co-authored 79 publications receiving 10892 citations. Previous affiliations of Georg Zeller include Max Planck Society & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Novel Drug Candidates for the Treatment of Metastatic Colorectal Cancer through Global Inverse Gene-Expression Profiling
Vera van Noort,Sebastian Schölch,Murat Iskar,Georg Zeller,Kristina Ostertag,Christine Schweitzer,Kristin Werner,Juergen Weitz,Moritz Koch,Peer Bork +9 more
TL;DR: One compound, citalopram, reduced tumor size as well as the number of circulating tumor cells and metastases in an orthotopic mouse model of colorectal cancer, illustrating the potential of systems pharmacology.
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AGRONOMICS1: A New Resource for Arabidopsis Transcriptome Profiling
Hubert Rehrauer,Catharine Aquino,Wilhelm Gruissem,Stefan R. Henz,Pierre Hilson,Sascha Laubinger,Naïra Naouar,Andrea Patrignani,Stephane Rombauts,Huan Shu,Yves Van de Peer,Marnik Vuylsteke,Detlef Weigel,Georg Zeller,Lars Hennig +14 more
TL;DR: The AGRONOMICS1 array is introduced, a new Affymetrix Arabidopsis microarray that contains the complete paths of both genome strands, with on average one 25mer probe per 35-bp genome sequence window, allowing for seamless integration of the very large existing ATH1 knowledge base.
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Quantitative RNA expression analysis with Affymetrix Tiling 1.0R arrays identifies new E2F target genes
Naïra Naouar,Klaas Vandepoele,Tim Lammens,Tineke Casneuf,Georg Zeller,Paul Van Hummelen,Detlef Weigel,Gunnar Rätsch,Dirk Inzé,Martin Kuiper,Lieven De Veylder,Marnik Vuylsteke +11 more
TL;DR: An approach to exploit this platform for quantitative mRNA expression analysis, and compare the results with those obtained using ATH1 arrays, and proposes a method for selecting unique tiling probes for each annotated gene or transcript in the most current genome annotation, TAIR7.
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Biosynthetic potential of the global ocean microbiome
Lucas Paoli,Hans-Joachim Ruscheweyh,Clarissa C. Forneris,Florian Hubrich,Satria A. Kautsar,Agneya Bhushan,Alessandro Lotti,Quentin Clayssen,Guillem Salazar,Alessio Milanese,Charlotte I. Carlström,Chrysa Papadopoulou,Dan Gehrig,Mikhail Karasikov,Harun Mustafa,Martin Larralde,Laura M. Carroll,Pablo Sánchez,Ahmed A. Zayed,Dylan R. Cronin,Silvia G. Acinas,Peer Bork,Chris Bowler,Tom O. Delmont,Josep M. Gasol,Alvar D. Gossert,André Kahles,Matthew B. Sullivan,Patrick Wincker,Georg Zeller,Serina L. Robinson,Jörn Piel,Shinichi Sunagawa +32 more
TL;DR: This paper investigated the diversity and novelty of biosynthetic gene clusters in the ocean by integrating around 10,000 microbial genomes from cultivated and single cells with more than 25,000 newly reconstructed draft genomes from more than 1,000 seawater samples.
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Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome
Sascha Laubinger,Georg Zeller,Stefan R. Henz,Sabine Buechel,Timo Sachsenberg,Jiawei Wang,Gunnar Rätsch,Detlef Weigel +7 more
TL;DR: The results suggest that the DCL1 is not only involved in miRNA action but also contributes to silencing of a subset of transposons, apparently through an effect on DNA methylation.