G
Georg Zeller
Researcher at European Bioinformatics Institute
Publications - 95
Citations - 14859
Georg Zeller is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 39, co-authored 79 publications receiving 10892 citations. Previous affiliations of Georg Zeller include Max Planck Society & Memorial Sloan Kettering Cancer Center.
Papers
More filters
Posted ContentDOI
SIAMCAT: user-friendly and versatile machine learning workflows for statistically rigorous microbiome analyses
Jakob Wirbel,Konrad Zych,Morgan Essex,Nicolai Karcher,Ece Kartal,Guillem Salazar,Peer Bork,Shinichi Sunagawa,Georg Zeller +8 more
TL;DR: The SIAMCAT R package is presented, a versatile and user-friendly toolbox for comparative metagenome analyses using machine learning, statistical tests, and visualization, and optimized the choice of ML algorithms and preprocessing routines for default workflow settings.
Journal ArticleDOI
Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial
Solomon A Sowah,Alessio Milanese,Ruth Schübel,Jakob Wirbel,Ece Kartal,Theron Johnson,Frank Hirche,Mirja Grafetstätter,T. S. Nonnenmacher,Romy Kirsten,Marina López-Nogueroles,Agustín Lahoz,Kathrin V. Schwarz,Jürgen G. Okun,Cornelia M. Ulrich,Johanna Nattenmüller,Arnold von Eckardstein,Daniel Müller,Gabriele I. Stangl,Rudolf Kaaks,Tilman Kühn,Georg Zeller +21 more
TL;DR: The HELENA trial as mentioned in this paper evaluated the effects of intermittent calorie restriction (ICR) operationalized as the 5:2 diet versus continuous calorie restriction on fecal microbiota of 147 overweight or obese adults in a 50-week parallel-arm randomized controlled trial.
Journal ArticleDOI
Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
Kenneth Peuker,Anne Strigli,Daniele V.F. Tauriello,Alexander Hendricks,Witigo von Schönfels,Greta Burmeister,Mario Brosch,A Herrmann,Sandra Krüger,Jessica Nitsche,Lea Južnić,Marc Marius Geissler,Andreas Hiergeist,André Gessner,Jakob Wirbel,Ruby Ponnudurai,Antje Tunger,Rebekka Wehner,Daniel E. Stange,Jürgen Weitz,Daniela Aust,Gustavo B. Baretton,Marc Schmitz,Christoph Röcken,Jochen Hampe,Sebastian Hinz,Georg Zeller,Triantafyllos Chavakis,Clemens Schafmayer,Eduard Batlle,Sebastian Zeissig +30 more
TL;DR: This article found that myeloid-specific deletion of calcineurin in mice activated protective CD8+ T cell responses and inhibited colorectal cancer (CRC) growth.
Journal ArticleDOI
Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial
Solomon A Sowah,Alessio Milanese,Ruth Schübel,Jakob Wirbel,Ece Kartal,Theron Johnson,Frank Hirche,Mirja Grafetstätter,Tobias Nonnenmacher,Romy Kirsten,Marina López-Nogueroles,Agustín Lahoz,Kathrin V. Schwarz,Jürgen G. Okun,Cornelia M. Ulrich,Johanna Nattenmüller,Arnold von Eckardstein,Daniel Müller,Gabriele I. Stangl,Rudolf Kaaks,Tilman Kühn,Georg Zeller +21 more
TL;DR: The HELENA trial as discussed by the authors evaluated the effects of intermittent calorie restriction (ICR) operationalized as the 5:2 diet versus continuous calorie restriction on fecal microbiota of 147 overweight or obese adults in a 50-week parallel-arm randomized controlled trial, the HELENA Trial.
Posted ContentDOI
Extensive Transmission of Microbes along the Gastrointestinal Tract
Thomas Schmidt,Matthew R. Hayward,Luis Pedro Coelho,Simone S. Li,Paul I. Costea,Anita Y. Voigt,Jakob Wirbel,Oleksandr M. Maistrenko,Renato J. Alves,Emma Bergsten,Carine de Beaufort,Iradj Sobhani,Anna Heintz-Buschart,Shinichi Sunagawa,Georg Zeller,Paul Wilmes,Peer Bork +16 more
TL;DR: Evidence is found for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens.