Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
Matilde Todaro,Mileidys Perez Alea,Anna Barbara Di Stefano,Patrizia Cammareri,Louis Vermeulen,Flora Iovino,Claudio Tripodo,Antonio Russo,Gaspare Gulotta,Jan Paul Medema,Giorgio Stassi +10 more
Reads0
Chats0
TLDR
The data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4, which strongly enhances the antitumor efficacy of standard chemotherapeutic drugs through selective sensitization of CD133(+) cells.About:
This article is published in Cell Stem Cell.The article was published on 2007-10-11 and is currently open access. It has received 1004 citations till now. The article focuses on the topics: Cancer stem cell & Lymphokine-activated killer cell.read more
Citations
More filters
Journal ArticleDOI
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
TL;DR: The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours.
Journal Article
Stem Cells,Cancer and Cancer Stem Cells
TL;DR: Research data show that more resistant stem cells than common cancer cells exist in cancer patients, and to identify unrecognized differences between cancer stem cells and cancer cells might be able to develop effective classification, diagnose and treat for cancer.
Journal ArticleDOI
Evolution of the Cancer Stem Cell Model
Antonija Kreso,John E. Dick +1 more
TL;DR: It is proposed that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity.
Journal ArticleDOI
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Louis Vermeulen,Felipe De Sousa E Melo,Maartje van der Heijden,Kate Cameron,Joan H. de Jong,Tijana Borovski,Jurriaan B. Tuynman,Matilde Todaro,Christian Merz,Hans M. Rodermond,Martin R. Sprick,Kristel Kemper,Dick J. Richel,Giorgio Stassi,Jan Paul Medema +14 more
TL;DR: It is proposed that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity.
Journal ArticleDOI
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
Zhizhong Li,Shideng Bao,Shideng Bao,Qiulian Wu,Qiulian Wu,Hui Wang,Christine E. Eyler,Sith Sathornsumetee,Qing Shi,Yiting Cao,Justin D. Lathia,Justin D. Lathia,Roger E. McLendon,Anita B. Hjelmeland,Anita B. Hjelmeland,Jeremy N. Rich +15 more
TL;DR: It is demonstrated that hypoxia-inducible factor HIF2alpha and multiple HIF-regulated genes are preferentially expressed in GSCs in comparison to non-stem tumor cells and normal neural progenitors.
References
More filters
Journal ArticleDOI
Stem cells, cancer, and cancer stem cells
TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
Journal ArticleDOI
Identification of human brain tumour initiating cells
Sheila K. Singh,Cynthia Hawkins,Ian D. Clarke,Jeremy A. Squire,Jane Bayani,Takuichiro Hide,R. Mark Henkelman,Michael D. Cusimano,Peter B. Dirks +8 more
TL;DR: The development of a xenograft assay that identified human brain tumour initiating cells that initiate tumours in vivo gives strong support for the CSC hypothesis as the basis for many solid tumours, and establishes a previously unidentified cellular target for more effective cancer therapies.
Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.
Journal ArticleDOI
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
TL;DR: The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem Cells.
Journal ArticleDOI
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani,Dario Giuseppe Lombardi,Emanuela Pilozzi,Mauro Biffoni,Matilde Todaro,Cesare Peschle,Ruggero De Maria +6 more
TL;DR: It is concluded that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies.