M
Mitchell S. Abrahamsen
Researcher at University of Minnesota
Publications - 69
Citations - 4509
Mitchell S. Abrahamsen is an academic researcher from University of Minnesota. The author has contributed to research in topics: Cryptosporidium parvum & Gene. The author has an hindex of 35, co-authored 69 publications receiving 4221 citations. Previous affiliations of Mitchell S. Abrahamsen include Montana State University.
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Journal ArticleDOI
Complete genome sequence of the apicomplexan, Cryptosporidium parvum.
Mitchell S. Abrahamsen,Thomas J. Templeton,Shinichiro Enomoto,Juan E. Abrahante,Guan Zhu,Cheryl A. Lancto,Mingqi Deng,Chang Liu,Giovanni Widmer,Saul Tzipori,Gregory A. Buck,Ping Xu,Alan T. Bankier,Paul H. Dear,Bernard Anri Konfortov,Helen Spriggs,Lakshminarayan M. Iyer,Vivek Anantharaman,L. Aravind,Vivek Kapur +19 more
TL;DR: Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients in the parasite, which lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome.
Journal ArticleDOI
The genome of Cryptosporidium hominis
Ping Xu,Giovanni Widmer,Yingping Wang,Luiz S. Ozaki,João M. P. Alves,Myrna G. Serrano,Daniela Puiu,Patricio Manque,Donna E. Akiyoshi,Aaron J. Mackey,Aaron J. Mackey,William R. Pearson,Paul H. Dear,Alan T. Bankier,Darrell L. Peterson,Mitchell S. Abrahamsen,Vivek Kapur,Saul Tzipori,Gregory A. Buck +18 more
TL;DR: The eight-chromosome ∼9.2-million-base genome of C. hominis shows a striking concordance with the requirements imposed by the environmental niches the parasite inhabits, and phenotypic differences between these parasites must be due to subtle sequence divergence.
Journal ArticleDOI
Comparative Analysis of Apicomplexa and Genomic Diversity in Eukaryotes
Thomas J. Templeton,Lakshminarayan M. Iyer,Vivek Anantharaman,Shinichiro Enomoto,Juan E. Abrahante,G.M. Subramanian,Stephen L. Hoffman,Mitchell S. Abrahamsen,L. Aravind +8 more
TL;DR: Additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available are described.
Book ChapterDOI
Cryptosporidium and Cryptosporidiosis
R.C.A. Thompson,Merle E. Olson,Guan Zhu,S Enomoto,S Enomoto,Mitchell S. Abrahamsen,Nawal Hijjawi +6 more
TL;DR: A review of the biology, biochemistry and host parasite relationships of Cryptosporidium can be found in this paper, where the authors highlight the uniqueness of this organism in terms of its parasite life style and evolutionary biology.
Journal ArticleDOI
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum
Jinling Huang,Nandita Mullapudi,Cheryl A. Lancto,Marla Scott,Mitchell S. Abrahamsen,Jessica C. Kissinger +5 more
TL;DR: The findings support the hypothesis that Cryptosporidium evolved from a plastid-containing lineage and subsequently lost its apicoplast during evolution and may be potential targets for therapeutic drugs owing to their phylogenetic distance or the lack of homologs in the host.