Giuseppe Mancia

TL;DR: It is becoming clear that out-of-office BP measurements have important prognostic value, and smooth control of 24-h BP may be of even greater importance, as the early morning BP surge, nighttime BP, and BP variability are associated with significant risk.

TL;DR: A large majority of echocardiographic examinations, routinely performed in hypertensive subjects in order to detect cardiac damage, do not report qualifying data on LV mass, LV geometry and diastolic function, indicating that a quantitative assessment of LVH and LV function is rarely provided in clinical practice.

TL;DR: The role of the central nervous system in determining the neuroadrenergic overdrive in heart failure has been reported since more than half a century as discussed by the authors, and the potential relevance as target of the therapeutic interventions based on non-pharmacological, pharmacological and invasive approaches, including the renal denervation, the splanchnic sympathetic nerve ablation and the carotid baroreflex stimulation, have been also gained on the active role exerted by the sympathetic activation on the disease outcome.

TL;DR: The overall evidence strongly suggests that the likelihood of LVH increases with the severity of OSA, thus exhibiting a continuous relationship.

TL;DR: The findings of the PAMELA study regarding the clinical aspects and prognostic significance of cardiac abnormal phenotypes such as left ventricular hypertrophy, left atrial dilatation and aortic root dilation are reviewed.