G
Giuseppe Mancuso
Researcher at University of Bologna
Publications - 27
Citations - 1121
Giuseppe Mancuso is an academic researcher from University of Bologna. The author has contributed to research in topics: Biology & Homo sapiens. The author has an hindex of 12, co-authored 21 publications receiving 914 citations. Previous affiliations of Giuseppe Mancuso include University of Cologne & University of Milan.
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Journal ArticleDOI
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
Sarah Ehses,Ines Raschke,Giuseppe Mancuso,Andrea Bernacchia,Stefan Geimer,Daniel Tondera,Jean-Claude Martinou,Benedikt Westermann,Elena I. Rugarli,Thomas Langer,Thomas Langer +10 more
TL;DR: The cleavage by OMA1 causes an accumulation of the short OPA1 variants, and the role ofm-AAA proteases in ensuring a balance of long and short Opa1 isoforms is investigated.
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Pleiotropic effects of spastin on neurite growth depending on expression levels
Elena Riano,Monica Martignoni,Giuseppe Mancuso,Daniele Cartelli,F. Crippa,Irene Toldo,Gabriele Siciliano,Daniela Di Bella,Franco Taroni,Maria Teresa Bassi,Graziella Cappelletti,Elena I. Rugarli +11 more
TL;DR: The study reveals that SPG4 is a dosage‐sensitive gene, and broadens the understanding of the role of spastin in neurite growth and MT dynamics, and supports haploinsufficiency as the molecular cause of the disease.
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Spastin binds to lipid droplets and affects lipid metabolism.
Chrisovalantis Papadopoulos,Genny Orso,Giuseppe Mancuso,Marija Herholz,Sentiljana Gumeni,Nimesha Tadepalle,Christian Jüngst,Anne Tzschichholz,Astrid Schauss,Stefan Höning,Aleksandra Trifunovic,Andrea Daga,Elena I. Rugarli +12 more
TL;DR: The data uncovers an evolutionarily conserved role of spastin as a positive regulator of LD metabolism and open up the possibility that dysfunction of LDs in axons may contribute to the pathogenesis of HSP.
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Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma
Marta Betti,Elisabetta Casalone,Daniela Ferrante,Anna Aspesi,Giulia Morleo,Alessandra Biasi,Marika Sculco,Giuseppe Mancuso,Simonetta Guarrera,Luisella Righi,Federica Grosso,Roberta Libener,Mansueto Pavesi,Narciso Mariani,Caterina Casadio,Renzo Boldorini,Dario Mirabelli,Barbara Pasini,Corrado Magnani,Giuseppe Matullo,Irma Dianzani +20 more
TL;DR: It is shown that germline variants in several genes may increase MPM susceptibility in the presence of asbestos exposure and may be important for specific treatment.
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The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors.
TL;DR: This work elucidates the molecular activity of d- and l-amino acids using an in vitro system based on a cellular model overexpressing sweet and bitter receptors, and provides the first systematic analysis of l- and d-aminos acid actions on the sweet heterodimeric receptor.