Gregory Dolganov

TL;DR: The microbial transcriptome served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen's cell envelope.

TL;DR: It is shown that O2 and low, nontoxic concentrations of NO competitively modulate the expression of a 48-gene regulon, which is expressed in vivo and prepares bacilli for survival during long periods of in vitro dormancy, and leads to a model postulating that, within granulomas, inhibition of respiration by NO production and O2 limitation constrains M. tuberculosis replication rates in persons with latent tuberculosis.

TL;DR: The results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma, including airway hyperreactivity and mucus overproduction.

TL;DR: It is concluded that even mild asthma is associated with goblet cell hyperplasia and increased stored mucin in the airway epithelium, whereas moderate asthma isassociated with increased stored bronchial mucin and secreted mucin.

TL;DR: A pathway in which the loss of integrin-mediated activation of latent TGF-β causes age-dependent pulmonary emphysema through alterations of macrophage Mmp12 expression is uncovered and it is shown that a functional alteration in the T GF-β activation pathway affects susceptibility to this disease.