Guanghui Ma

TL;DR: Data indicated that a maximum immune response can be achieved by controlling properties of chitosan microgels, which also could serve as a significant guidance for rational design of ch itosan-based particle adjuvant.

TL;DR: In this paper, the gigaporous PS microspheres were chemically modified with polyvinyl alcohol (PVA) through two-step reaction, and they were characterized by Fourier transform infrared (FTIR) spectra, X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), mer- cury porosimetry measurements (MPM), and protein adsorption measurements, laser scanning confocal microscope (LSCM).

TL;DR: Among excipients tested, sucrose and glycerol provided the best protection, such that the half-life of 146S in solution at 45°C could be prolonged from less than 30min to more than 3days by adding 20% sucrose.

TL;DR: These investigations supply a practical approach for the site-specific modification of proteins with an N-terminal serine or threonine to achieve improved homogeneity of the conjugates as well as enhanced pharmacological properties.

TL;DR: This work provides a strong empirical foundation that nanovaccine researchers should position delivery mode near the top of their considerations for the experimental design, which should speed up nanvaccine development and facilitate efficient selection of appropriate delivery modes in the clinic.