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Gudrun M. Jonsdottir
Researcher at deCODE genetics
Publications - 7
Citations - 3899
Gudrun M. Jonsdottir is an academic researcher from deCODE genetics. The author has contributed to research in topics: Population & Recombination. The author has an hindex of 7, co-authored 7 publications receiving 3730 citations.
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Journal ArticleDOI
A high-resolution recombination map of the human genome
Augustine Kong,Daniel F. Gudbjartsson,Jesus Sainz,Gudrun M. Jonsdottir,Sigurjon A. Gudjonsson,Bjorgvin Richardsson,Sigrun Sigurdardottir,John Barnard,Bjorn Hallbeck,Gisli Masson,Adam Shlien,Stefan T Palsson,Michael L. Frigge,Thorgeir E. Thorgeirsson,Jeffrey R. Gulcher,Kari Stefansson +15 more
TL;DR: Recombination rates are significantly correlated with both cytogenetic structures and sequence and paternal chromosomes show many differences in locations of recombination maxima, suggesting that there is some underlying component determined by both genetic and environmental factors that affects maternal recombination rates.
Journal ArticleDOI
A common inversion under selection in Europeans
Hreinn Stefansson,Agnar Helgason,Gudmar Thorleifsson,Valgerdur Steinthorsdottir,Gisli Masson,John Barnard,Adam Baker,Aslaug Jonasdottir,Andres Ingason,Vala G. Gudnadottir,Natasa Desnica,Andrew A. Hicks,Arnaldur Gylfason,Daniel F. Gudbjartsson,Gudrun M. Jonsdottir,Jesus Sainz,Kari Agnarsson,Birgitta Birgisdottir,Shyamali Ghosh,Adalheidur Olafsdottir,Jean-Baptiste Cazier,Kristleifur Kristjansson,Michael L. Frigge,Thorgeir E. Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Kari Stefansson +26 more
TL;DR: It is shown that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers.
Journal ArticleDOI
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Daniel F. Gudbjartsson,Unnur S. Bjornsdottir,Unnur S. Bjornsdottir,Eva Halapi,Anna Helgadottir,Patrick Sulem,Gudrun M. Jonsdottir,Gudmar Thorleifsson,Hafdis T. Helgadottir,Valgerdur Steinthorsdottir,Hreinn Stefansson,Carolyn Williams,Jennie Hui,John Beilby,Nicole M. Warrington,Alan L. James,Alan L. James,Lyle J. Palmer,Gerard H. Koppelman,Andrea Heinzmann,Marcus Krueger,H. Marike Boezen,Amanda Wheatley,Janine Altmüller,Hyoung Doo Shin,Soo-Taek Uh,Hyun Sub Cheong,Brynja Jonsdottir,David Gislason,Choon-Sik Park,Linda M. Rasmussen,Celeste Porsbjerg,Jakob Werner Hansen,Vibeke Backer,Thomas Werge,Christer Janson,Ulla-Britt Jönsson,Maggie C.Y. Ng,Juliana C.N. Chan,Wing-Yee So,Ronald C.W. Ma,Svati H. Shah,Christopher B. Granger,Arshed A. Quyyumi,Allan I. Levey,Viola Vaccarino,Muredach P. Reilly,Daniel J. Rader,Michael J.A. Williams,Andre M. van Rij,Gregory T. Jones,Elisabetta Trabetti,Giovanni Malerba,Pier Franco Pignatti,Attilio Boner,Lydia Pescollderungg,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Bjorn R. Ludviksson,Dora Ludviksdottir,Gudmundur I. Eyjolfsson,David O. Arnar,Gudmundur Thorgeirsson,Klaus A. Deichmann,Philip J. Thompson,Matthias Wjst,Ian P. Hall,Dirkje S. Postma,Thorarinn Gislason,Jeffrey R. Gulcher,Augustine Kong,Ingileif Jonsdottir,Ingileif Jonsdottir,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +77 more
TL;DR: A genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly with myocardial infarction in six different populations.
Journal ArticleDOI
Sequence variants in the RNF212 gene associate with genome-wide recombination rate.
Augustine Kong,Gudmar Thorleifsson,Hreinn Stefansson,Gisli Masson,Agnar Helgason,Daniel F. Gudbjartsson,Gudrun M. Jonsdottir,Sigurjon A. Gudjonsson,Sverrir T. Sverrisson,Theodora Thorlacius,Aslaug Jonasdottir,Gudmundur A. Hardarson,Stefan T Palsson,Michael L. Frigge,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Kari Stefansson +16 more
TL;DR: It is noteworthy that the haplotype formed by two single-nucleotide polymorphisms associated with the highest recombinations in males is associated with a low recombination rate in females, which means that if the frequency of the haplotypes changes, the average recombinations will increase for one sex and decrease for the other, but the sex-averaged recombination rates of the population can stay relatively constant.
Journal ArticleDOI
Recombination rate and reproductive success in humans
Augustine Kong,John Barnard,Daniel F. Gudbjartsson,Gudmar Thorleifsson,Gudrun M. Jonsdottir,Sigrun Sigurdardottir,Bjorgvin Richardsson,Jonina Jonsdottir,Thorgeir E. Thorgeirsson,Michael L. Frigge,Neil E. Lamb,Stephanie L. Sherman,Jeffrey R. Gulcher,Kari Stefansson +13 more
TL;DR: This work examined genome-wide microsatellite data for 23,066 individuals, providing information on recombination events of 14,140 maternal and paternal meioses each, and found a positive correlation between maternal recombination counts of an offspring and maternal age.