H
Heather Ogana
Researcher at University of Southern California
Publications - 22
Citations - 225
Heather Ogana is an academic researcher from University of Southern California. The author has contributed to research in topics: Integrin & Leukemia. The author has an hindex of 6, co-authored 16 publications receiving 93 citations. Previous affiliations of Heather Ogana include Children's Hospital Los Angeles.
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Journal ArticleDOI
Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia.
Aaron Kruse,Nour Abdel-Azim,Hye Na Kim,Yongsheng Ruan,Valerie Phan,Heather Ogana,William Wang,Rachel Lee,Eun Ji Gang,Sajad Khazal,Yong-Mi Kim +10 more
TL;DR: Current methods to diagnose MRD through phenotypic marker patterns or differential gene patterns through analysis by flow cytometry, polymerase chain reaction (PCR), real-time quantitative polymerasechain reaction (RQ-PCR, reverse transcription polymeraseChain reaction (RT-PCr) or NGS are reviewed.
ComponentDOI
Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.
Starlynn Clarke,Biao Ma,Nathan D. Trinklein,Ute Schellenberger,Michael J. Osborn,Laure-Hélène Ouisse,Andrew Boudreau,Laura Davison,Katherine E. Harris,Harshad Ugamraj,Aarti Balasubramani,Kevin Dang,Brett Jorgensen,Heather Ogana,Duy Pham,Payal Pratap,Preethi Sankaran,Ignacio Anegon,W.C. van Schooten,Marianne Brüggemann,Roland Buelow,S. Force Aldred +21 more
TL;DR: This work presents an innovative platform for the rapid development of diverse sets of human HCAbs that have been selected in vivo and combines antibody repertoire analysis with immunization of transgenic rats, called UniRats, that produce chimeric HCABS with fully human VH domains in response to an antigen challenge.
Journal ArticleDOI
Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia.
Eun Ji Gang,Hye Na Kim,Yao-Te Hsieh,Yongsheng Ruan,Heather Ogana,Solomon Lee,Jennifer Pham,Huimin Geng,Eugene Park,Lars Klemm,Cheryl L. Willman,William L. Carroll,Steven D. Mittelman,Etan Orgel,Matthew J. Oberley,Chintan Parekh,Hisham Abdel-Azim,Deepa Bhojwani,Alan S. Wayne,Adèle De Arcangelis,Elisabeth Georges-Labouesse,Elizabeth Wayner,Halvard Bonig,Halvard Bonig,Aspram Minasyan,Johanna ten Hoeve,Thomas G. Graeber,Markus Müschen,Nora Heisterkamp,Yong-Mi Kim +29 more
TL;DR: The data support α6 as a novel therapeutic target for ALL by demonstrating that in vivo deletion of α6 in combination with tyrosine kinase inhibitor (TKI) treatment was more effective in eradicating ALL than treatment with a TKI (nilotinib) alone.
Journal ArticleDOI
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.
Katherine E. Harris,Shelley Force Aldred,Laura Davison,Heather Ogana,Andrew Boudreau,Marianne Brüggemann,Michael J. Osborn,Biao Ma,Benjamin Buelow,Starlynn Clarke,Kevin Dang,Suhasini Iyer,Brett Jorgensen,Duy Pham,Payal Pratap,Udaya Rangaswamy,Ute Schellenberger,Wim Van Schooten,Harshad Ugamraj,Omid Vafa,Roland Buelow,Nathan D. Trinklein +21 more
TL;DR: The results demonstrate that OmniFlic animals produce an abundance of antigen-specific antibodies with heavy chain clonotype diversity that is similar to what has been described with unrestricted light chain use in mammals and shows that sequence-based discovery is a highly effective and efficient way to identify a large number of diverse monoclonal antibodies to a protein target of interest.
Journal ArticleDOI
Cadherins, Selectins, and Integrins in CAM-DR in Leukemia.
TL;DR: The role of cadherin, selectin, and integrin correlates with the increased drug resistance of leukemia cells and the results of clinical trials targeting these molecules are reviewed.