Heather Ogana

TL;DR: Current methods to diagnose MRD through phenotypic marker patterns or differential gene patterns through analysis by flow cytometry, polymerase chain reaction (PCR), real-time quantitative polymerasechain reaction (RQ-PCR, reverse transcription polymeraseChain reaction (RT-PCr) or NGS are reviewed.

TL;DR: This work presents an innovative platform for the rapid development of diverse sets of human HCAbs that have been selected in vivo and combines antibody repertoire analysis with immunization of transgenic rats, called UniRats, that produce chimeric HCABS with fully human VH domains in response to an antigen challenge.

TL;DR: The data support α6 as a novel therapeutic target for ALL by demonstrating that in vivo deletion of α6 in combination with tyrosine kinase inhibitor (TKI) treatment was more effective in eradicating ALL than treatment with a TKI (nilotinib) alone.

TL;DR: The results demonstrate that OmniFlic animals produce an abundance of antigen-specific antibodies with heavy chain clonotype diversity that is similar to what has been described with unrestricted light chain use in mammals and shows that sequence-based discovery is a highly effective and efficient way to identify a large number of diverse monoclonal antibodies to a protein target of interest.

TL;DR: The role of cadherin, selectin, and integrin correlates with the increased drug resistance of leukemia cells and the results of clinical trials targeting these molecules are reviewed.